Dr. Dace Pjanova
Tenured Professor Riga Stradiņš University, Latvia
Project: “Whole exome sequencing to advance melanoma early detection”
Background:
Knowing genetic markers help identify high risk individuals who will benefit from earlier screenings. For hereditary forms of melanoma, currently known genetic factors cannot fully explain familiar clustering. Dace and her team search for rare and unknown linkage between genetic mutations and elevated risks for certain cancer types – including Melanoma.
Knowing genetic markers help identify high risk individuals who will benefit from earlier screenings. For hereditary forms of melanoma, currently known genetic factors cannot fully explain familiar clustering. Dace and her team search for rare and unknown linkage between genetic mutations and elevated risks for certain cancer types – including Melanoma.
canSERV services:
Rare disease-related genetic markers can often only be identified by analysing divers datasets. The organisation of the human genome, with only ~2% coding regions, needs specialised techniques to screen the datasets. Dace’s team applied to whole exome sequencing of Melanoma patients recruited for the Latvian Genome database (LGDB) and a training to search the datasets for unknown causal genes for Melanoma and related cancer types.
Rare disease-related genetic markers can often only be identified by analysing divers datasets. The organisation of the human genome, with only ~2% coding regions, needs specialised techniques to screen the datasets. Dace’s team applied to whole exome sequencing of Melanoma patients recruited for the Latvian Genome database (LGDB) and a training to search the datasets for unknown causal genes for Melanoma and related cancer types.
Societal and Patients Impact:
A known genetic predisposition for Melanoma allows better targeted screening, which will lead to ealier diagnosis and will increase the chance of rapid and successful treatment and intervention.
A known genetic predisposition for Melanoma allows better targeted screening, which will lead to ealier diagnosis and will increase the chance of rapid and successful treatment and intervention.
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