Field 2 – Advanced technologies for Personalised Oncology

This field will provide the cancer research community with access to cutting-edge services and technologies, as well as the associated expertise in their use, to address cancer research questions at a molecular, cellular and whole organism level. The technologies and services offered are closely interlinked with the services and tools in field 1, 3 and 4. This close interlink and collaboration will provide researchers with the opportunity to build service pipelines combining access to advanced technologies for using and analysing cancer models provided by field 1, as well as the tools and technologies needed in their search and validation of new biomarkers (field 3) and new treatments (field 4).

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Unique ID	Country	Service Name	Description of Service	Research Infrastructure	Service Provider	Unit of acces	Website
2.29d_BRFAA	GR	Tissue slice culture	Fresh solid tumors from humans or mice are embedded in agarose and sectioned at 150-300 um using a Compresstome® tissue slicer. Slices can be grown in appropriate media for up to one week in Transwell inserts. They can be used for drug testing, immune cell co-cultures, migration studies and other applications.	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	https://www.bioacademy.gr
2.23_DNS_Uo Lubeck	DE	Image Cytometry	Genomic instability assessment by nuclear DNA ploidy measurements by means of image cytometry using Feulgen stained cytospins or imprints. At least 500 nuclei per sample are selected interactively and the DNA content is measured quantitatively using the ACAS imaging system (Ahrens ACAS, Germany). The DNA profiles are classified according to Auer.	BBMRI-ERIC	Section for Translational Surgical Oncology & Biobanking, Department of Surgery	Sample	https://www.uni-luebeck.de/ncch/lion.html
2.19e_UZL-qMS	DE	Quantatitve mass spectrometry	Semi-quantitative data-independent mass spectrometry (DIA) making use of a state-of-the-art hybrid trapped ion mobility spectrometry - quadrupole time of flight (TOF) mass spectrometer in parallel accumulation-serial fragmentation (PASEF) mode coupled to nano-flow liquid chromatography. Mass spectrometric raw data are analyzed with the DIA-NN workflow and the library-free mode.	BBMRI-ERIC	Section for Translational Surgical Oncology & Biobanking, Department of Surgery	sample	https://www.uni-luebeck.de/ncch/lion.html
2.12c_IRST IRCCS	IT	Confocal Microscope	Multimodal advanced light microscopy and super-resolution microscopy, including live cell imaging and functional imaging for characterisation and validation of disease models and confocal microscopy.	BBMRI-ERIC	Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amatori" IRST IRCCS	cell lines	https://www.irst.emr.it
2.18l_IRST IRCCS	IT	Whole genome sequencing	Whole genome sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amatori" IRST IRCCS	sample	https://www.irst.emr.it
2.18m_nCounter_IRST	IT	Target RNA analysis	Target RNA analysis (up to 800 targets per assay) using the nCounter Nanostring platform	BBMRI-ERIC	Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amatori" IRST IRCCS	sample	https://www.irst.emr.it
2.3a_CliniMacs_IRST	IT	ATMPs Production	Cell Factory for ATMPs production of nanoparticles for RNA delivery	BBMRI-ERIC	Istituto Scientifico Romagnolo per lo Studio dei Tumori "Dino Amatori" IRST IRCCS	Nanoparticle	https://www.irst.emr.it
2.2b_UNIMIB Med	IT	Laser Dissection	Digital pathology and Machine Learning -based image analysis; quality-controlled digitized whole-slide histological images of tumour and parallel normal tissue including annotated pathological and survival data	BBMRI-ERIC	UNIMIB_Pathology	sample	https://en.unimib.it/
2.2c_UNIMIB	IT	Digital Pathology	Dissector with laser acquisition of specific single cells or tissue areas for different uses, including omics	BBMRI-ERIC	UNIMIB_Laser Dissection	sample	https://en.unimib.it/
2.19c+.24c_UNIMIB Med	IT	Proteomic_Metabolomic	Proteomics - MS/MS and MALDI Imaging Platform; Quantitative MS, quatitative Mass Spectrometry, Lipidomics and Metabolomics	BBMRI-ERIC	UNIMIB_Proteomic_Metabolomic	Sample	https://en.unimib.it/
2.18k	IT	Whole genome sequencing	Whole genome sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	UNIMIB_Genomic	cell	https://en.unimib.it/
2.21a_UNIMIB	IT	Nanomedicine	Development of devices for: a) more efficient intracellular and controlled release of drugs, in particular co-delivery of antigens with immunostimulatory adjuvants , b) protection of antigen payloads and other bioactive molecules, c) increasing antigen bioavailability by encapsulation, adsorption or surface functionalization; d) decreased toxicity; efficient lymphatic drainage, enhanced permeability and retention effect at the tumour site	BBMRI-ERIC	UNIMIB_Nanomedicine	samples	https://en.unimib.it/
2.18u_Single cell _LIED	DE	Single cell mRNA sequencing	Single cell mRNA sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	Lübeck Institute of Experimental Dermatology	sample	https://www.lied.uni-luebeck.de/home.html
2.18j_CNAG	ES	Whole genome sequencing	Whole genome sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	Centro Nacional de Análisis Genómico	1Gbsequence data	https://www.cnag.crg.eu/
2.18i_AOU-BO-MSS	IT	Target DNA/RNA sequencing: Oncomine Focus assay	Target DNA and RNA sequencing of hot spot genes, copy number gene variation and gene fusion (Oncomine Focus assay) of tumoral/non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	IRCCS Azienda Ospedaliero Universitaria di Bologna	Sample	https://www.aosp.bo.it/
2.18h_AOU-BO-MASS	IT	Target DNA Sequencing: custom gene panels	Target sequencing of custom gene panels (hotspot genes) in tumoral and non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	IRCCS Azienda Ospedaliero Universitaria di Bologna	Sample	https://www.aosp.bo.it/
2.12b_BL2_NIL	PL	Confocal Imaging	2D/3D Imaging of living or fixed stained specimen by confocal microscopy equipped with 488, 543, 633 nm lasers, 4-100x objectives.	BBMRI-ERIC	Department of Biomedical Research / Translational Research Laboratory	Cell line	https://www.nil.gov.pl
2.35a_BL2_NIL	PL	Molecular Modeling - Docking	Binding analysis of compounds to specific proteins to understand anticancer molecular mechanisms of action	BBMRI-ERIC	Department of Biomedical Research / Translational Research Laboratory	project	https://www.nil.gov.pl
2.35b_BL2_NIL	PL	Molecular Modeling - Dynamics	LIgand-protein interactions and conformational analysis of proteins upon ligand binding	BBMRI-ERIC	Department of Biomedical Research / Translational Research Laboratory	project	https://www.nil.gov.pl
2.35c_BL2_NIL	PL	Molecular Modelingt - ab inito	ADME (Absorption, Distribution, Metabolism, and Excretion) properties of tested compounds and evaluation of the conformational stability of molecules	BBMRI-ERIC	Department of Biomedical Research / Translational Research Laboratory	projects	https://www.nil.gov.pl
2.28a_NMI	PL	Flow Cytometry	Flow cytometry technique (FACSCanto II flow cytometer) to detect apoptotic cells and mitochondrial membrane potential . Cell cycle analysis can be conducted.	BBMRI-ERIC	Department of Biomedical Research / Translational Research Laboratory	Cell	https://www.nil.gov.pl
2.17a_imag. radiomic_ATMA	IT	Radiomics	Prospective collection of diagnostic images (MR, CT, PT) of cancer patients and advanced imaging analysis (MR, CT, PT)	BBMRI-ERIC	ATMA Expert Center	diagnostic image
2.17b_imag. radiomics_ATMA	IT	Radiomics	Advanced imaging analysis for early diagnosis and treatment response. It includes radiomic analysis and features selection to develop oncological personalized models.	BBMRI-ERIC	ATMA Expert Center	diagnostics image
2.18o_UNIBO-Microbiome Unit	IT	16S rRNA microbiome sequencing	Microbial profiling using 16S ribosomal RNA (rRNA) next generation sequencing technologies	BBMRI-ERIC	UNIBO-Microbiome Unit	sample	https://dimec.unibo.it/it
2.18p_UNIBO Microbiome Unit	IT	Metagenomic microbiome sequencing	Microbial profiling using shotgun metagenomic NGS technologies	BBMRI-ERIC	UNIBO-Microbiome Unit	sample	https://dimec.unibo.it/it
2.18n_UNIBO Microbiome Unit	IT	Metatranscriptomic microbiome sequencing	Microbial profiling using shotgun metatranscriptomic next generation sequencing technologies	BBMRI-ERIC	UNIBO-Microbiome Unit	sample	https://dimec.unibo.it/it
2.28b_LTTA-FE	IT	Flow Cytometry	Multiparametric immunophenotyping based on the use of specific fluorescent antibodies to measure targeted proteins expression within a cell population by flow cytometer, to investigate cancer severity, clonal expansion, proliferation, survival and differentiation in response to specific treatments of cancerous cells. Phenotypic characterization of the labeled cells as well as their sorting is available for further investigation.	BBMRI-ERIC	Laboratorio per le Tecnologie delle Terapie Avanzate	sample	https://www.ltta.tecnopoloferrara.it
2.19b_LTTA-FE	IT	Luminex multiplexing	Cytokines/chemochines quantitative multiparametric analysis, important for understanding the role of inflammation in cancer diseases. Luminex technology permits rapid and accurate analysis of panels of analytes (up to 50 at a time) in small sample volumes (25 µl) of serum/plasma or culture media.	BBMRI-ERIC	Laboratorio per le Tecnologie delle Terapie Avanzate	project	https://www.ltta.tecnopoloferrara.it
2.18f_UL Biobank	PL	Whole Genome Sequencing	Whole genome sequencing in tumoral and non tumoral samples using NGS technologies	BBMRI-ERIC	University of Lodz - Biobank Lodz	1 Gb of sequencing data	https://www.biobank.uni.lodz.pl
2.18g_PanCan NGS	IT	Target DNA sequencing: actionable genes	Target sequencing of actionable genes in tumoral and non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	University Verona	sample	https://www.univr.it
2.30a_Neuro.path	AT	Chemosensitivity assays	Chemosensitivity testing of tumor cells after treatment, helping to find best suitable drugs for respective patients. Proper concentrations of drugs are used, in order to make the results transferable for clinical use. Establishment of molecular tumor board is supported by introducing this technology.	BBMRI-ERIC	Institut of Pathology, Neuropathology and Molecular Pathology	sample	https://www.i-med.ac.at/research-report/NeuroMolPathology.html
2.12a_Neuro.path	AT	Histology, Immunohistochemistry, Immunofluorescence, Cytology, Molecular pathology, diagnostics, confocal microscopy	Histological assessment of respective samples, immunohistochemical and immunofluorescence staining for different biomarkers, confocal microscopy, morphometrics; morphological assessment support by A.I. tools available.	BBMRI-ERIC	Institut of Pathology, Neuropathology and Molecular Pathology	sample	https://www.i-med.ac.at/research-report/NeuroMolPathology.html
2.18d_NCI-LT-Seq-DM	LT	Target DNA sequencing: custom gene panels	Target sequencing of custom gene panels in tumoral and non tumoral samples using Next Generation Sequencing technologies	BBMRI-ERIC	Laboratory of Genetic Diagnostic	sample	https://www.nvi.lt/laboratory-of-genetic-diagnostic/
2.18a_Pannoramic MIDI	CZ	Digital Pathology	Whole-slide histological images of tumor and parallel normal tissues that are stored in Bank of Biological Materials including basic histopathological data	BBMRI-ERIC	Department of Pathology	sample	https://www.mou.cz/en/
2.18c_Multipotentiostat	CZ	Electrochemical biosensors	Construction of electrochemical biosensors for detection of DNA and/or RNA biomarkers: e.g. detection of HPV (genotyping HPV 16 and 18), SNPs, DNA methylations, miRNAs, lncRNA etc.	BBMRI-ERIC	RECAMO	sample	https://www.mou.cz/en/
2.2a_Droplet Dig. PCR	CZ	Digital PCR	Detection of tumour biomarkers (miRNA, DNA mutations, CNVs) in tumour biopsies, cell free DNA, circulating tumor cells, etc.	BBMRI-ERIC	RECAMO	sample	https://www.mou.cz/en/
2.18b_NextSeq 500	CZ	Target DNA sequencing: custom gene panels	Target sequencing of custom gene panels in tumoral and non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	RECAMO	sample	https://www.mou.cz/en/
2.18q_BRFAA	GR	Target DNA sequencing: custom gene panels	Target sequencing of custom gene panels in tumoral and non tumoral samples using next generation sequencing technologies	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.18r_BRFAA	GR	Target DNA sequencing: hereditary cancer	Target sequencing of genes involved in hereditary cancer using next generation sequencing technologies	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.18s_BRFAA	GR	Target DNA sequencing: hematological malignancies	Target sequencing of genes involved in hematological malignancies using next generation sequencing technologies	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.18t_BRFAA	GR	Target DNA sequencing: TruSight Oncology 500	Target sequencing of >500 genes relevant for solid tumors using next generation sequencing technologies	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.16a_BRFAA	GR	PET-CT in mice	Preclinical PET/CT imaging with a state-of-the-art microPET/CT scanner and sophisticated image processing software for analyzing and quantifying PET and CT images of mice and rats. Appropriate racks for hosting animals for a long period of time are available. For more info please visit: https://www.infrafrontier.gr/whole-body-imaging-petct	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.16b_BRFAA	GR	PET-CT and exome-seq in mice	Preclinical PET-CT imaging and exome-sequencing in 1 mouse to reveal genetic variants that alter protein sequences. The Greek Genome Center is equipped with state-of-the-art Illumina sequencers, automated high throughput DNA/RNA extraction and liquid handling workstations and, finally, a high-performance computing cluster.	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.19d_BRFAA	GR	CyTOF analysis	BRFAA mass cytometry unit provides a comprehensive full service, including data analysis, to evaluate cellular phenotype of human and mouse samples including: extracellular and intracellular markers of cell identity, cytokine production, signaling phenotypes and cellular division. We employ multiparametric panels of antigenic markers (>20 markers) with pre-made kits or customizable ones. Examples of such panels can be found at website https://www.brfaacytoflab.com/other-resources.	BBMRI-ERIC	Biomedical Research Foundation of the Academy of Athens	sample	http://www.bioacademy.gr/
2.1a_IVM_CNR	IT	Intravital microscopy (IVM) with fluorescent biosensors in mouse models of cancer	Intravital microscopy (IVM) is the study of localization and dynamics of cellular processes relevant to cancer within the native tumor microenvironment. Services include housing of mice, surgical procedures necessary for installation of optical imaging windows adjacent to an tumors/organ of interest. Cancer model may include orthotopic/ectopic xenograft models in immunodeﬁcient, syngeneic mouse tumor cell lines that can be genetically modified to express ﬂuorescent reporters proteins for imaging purposes and genetic mouse models engineered to develop cancer.	INFRAFRONTIER	Consiglio Nazionale delle Ricerche	projects	http://www.ibbc.cnr.it
2.1b_Fluorescent biosensors	FI	Intravital microscopy (IVM) with fluorescent biosensors in mouse models of cancer	Intravital microscopy (IVM) is the study of localization and dynamics of cellular processes relevant to cancer within the native tumor microenvironment. Services include housing of mice, surgical procedures necessary for installation of optical imaging windows adjacent to an tumors/organ of interest. Cancer model may include orthotopic/ectopic xenograft models in immunodeﬁcient, syngeneic mouse tumor cell lines that can be genetically modified to express ﬂuorescent reporters proteins for imaging purposes and genetic mouse models engineered to develop cancer.	INFRAFRONTIER	University of Oulu	projects	https://www.oulu.fi/en/university/faculties-and-units/biocenter-oulu
2.2_Dig. path_Oulu	FI	Digital pathology and ML-based image analysis	This service offers quality-controlled digitized whole-slide histological images of tumour and parallel normal tissue, including annotated pathological and survival data and dissector with laser acquisition.	INFRAFRONTIER	University of Oulu	projects	https://www.oulu.fi/en/university/faculties-and-units/biocenter-oulu
2.1b_ISS Core	IT	Imaging evaluation of murine model during cancer development and treatment	Advanced and quantitative in vivo MRI and MRS to characterize rodents models of cancer during cancer development and following treatment. In particular: DWI with different diffusion models for functional characterization, molecular imaging with iron oxide or 19F nanoparticles for macrofages recruitment studies and quantitative 1H, 31P and 19F MRS for cancer model metabolic characterization.	EATRIS	Istituto Superiore di Sanità (ISS)	MRI and MRS analyses	https://www.iss.it/
2.28_Sort FCM	IT	Cell sorting of target population	Cell sorting of target population (e.g. rare population,..), identified by flow or mass cytometry in human tissues	EATRIS	Istituto Superiore di Sanità (ISS)	hour	https://www.iss.it/
2.49_Alonso MJ	ES	Immunocompetent murine models of cancer for antitumoral efficacy evaluation	Evaluation of immunocompetent murine models of cancer for antitumoral efficacy, including effects on the tumor microenvironment. Expertise in (1) subcutaneous murine models of any type of cancer; (2) orthotopic immunocompetent models of fibrosarcoma or lung cancer, presenting a high infiltration of tumor-associated macrophages (i.e. MN/MCA or CMT167).	EATRIS	Health Research Institute of Santiago de Compostela (IDIS)	Immunocompetent murine models	https://www.idisantiago.es/
2.50_Mol.Biol of Cancer	CZ	Monochrome Multiplex Real-Time qPCR Assay for telomere measurement	Monochrome Multiplex Real-Time qPCR Assay for telomere measurement affected by incomplete DNA replication of a lagging strand or by genotoxic effect of environmental and intracellular DNA-damaging agents, including anticancer drugs.	EATRIS	Institute of Experimental Medicine CAS	experiment/set of 100 samples	http://www.iem.cas.cz/en/institute/
2.26_Mol.Boiol of Cancer	CZ	Comet assay (single-cell gel electrophoresis) for measuring DNA strand breaks and oxidative DNA damage	The comet assay (single-cell gel electrophoresis) is a simple method for measuring DNA strand breaks and oxidative DNA damage (Opattova, Horak et al. 2019). This method is applicable for human biomonitoring, testing novel chemicals for genotoxicity, environmental contamination with genotoxins and molecular epidemiology.	EATRIS	Institute of Experimental Medicine CAS	experiment/set of 20 samples	http://www.iem.cas.cz/en/institute/
2.48_SDN	IT	Assays for in vitro discovery research	Cell cycle, apoptosis, proliferation and phosflow assay for in vitro discovery research (i.e. drug discovery, pathway analysis)	EATRIS	NETWORK OF NEUROSCIENCE AND NEUROREHABILITATION IRCCS	sample	https://www.reteneuroscienze.it/en/Istituto/irccs-sdn-istituto-di-ricerca/
2.16_Mol. imag. biomarkers	ES	microPET/CT acquisition dynamic on murine model	The service includes model generation (if possible in-house), animal handling, dynamic image acquisition and image post-processing. The radiotracer cost is included for radiotracers synthesized at our cyclotron or radiopharmacy facilities (18F-FDG, 18F-FLT, 18F-FMISO, 18F-choline,18F-DOPA, 68Ga-PSMA, 68Ga-DOTATOC). Unit of access includes animal housing and handling, radiotracer, and image processing after the experiment. Deliverables are: dynamic PET/CT images, full quantitative analysis report	EATRIS	Health Research Institute of Santiago de Compostela (IDIS)	1 animal (sample)	https://www.idisantiago.es/
2.11_Molecul. imag. Biomarkers	ES	mAbs labelling: Labelling of novel mAbs with 89Zr for PET imaging.	Labelling of novel mAbs with 89Zr for PET imaging.	EATRIS	Health Research Institute of Santiago de Compostela (IDIS)	mAbs labelling	https://www.idisantiago.es/
2.19a_IBET	PT	Advanced Mass Spectrometry for the Characterization of Molecular Tools	The service includes Protein/peptide identification, Antibody Characterization using Multi-Attribute Method (MAM), Post-Translational Modifications Analysis (Glycosylation; Oxidation/Deamination, Glycan Identity…), High-throughput Quantitative Proteomics – SWATH analysis (untargeted; relative quantification), Quantitative Proteomics/peptidomics - MRM-HR (targeted) (relative and/or absolute quantitation) and Intact Protein Measurement.	EATRIS	iBET - Instituto de Biologia Experimental e Tecnológica	Samples+Controls+Standards	https://www.ibet.pt/
2.19b_IBET	PT	Characterization of Molecular Tools - Aggregation and refolding (SEC and RP chromatography)	Reverse phase (RP) and Size Exclusion Chromatography (SEC) to assess information on identity and purity attributes of protein-based biopharmaceuticals. SEC is applied for analysis of monomers, dimers, aggregates and degradation products according to their size. RP contributes to characterization of the product in terms of hydrophobicity.	EATRIS	iBET - Instituto de Biologia Experimental e Tecnológica	Sample (2 runs) + dedicated column	https://www.ibet.pt/
2.15b+2.46b_Bruker	AT	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents, image data processing and analysis.	EURO-BIOIMAGING	Austrian BioImaging	hour	https://www.eurobioimaging.eu/nodes/austrian-bioimagingcmi
2.15c+2.46c_Vevo US	AT	Preclinical UltraSound imaging	UltraSound Imaging of animal models for visualizing and quantifying tumors, allowing staging, monitoring of therapeutic treatments, or guided injection of drugs. The use of targeting microbubbles as US contrast agents allows the visualization and quantification of specific tumor biomarkers as well. The service includes animal model preparation, probes, image data processing and analysis.	EURO-BIOIMAGING	Austrian BioImaging	hour	https://www.eurobioimaging.eu/nodes/austrian-bioimagingcmi
2.12a+2.33a+2.40a_live cell	BG	Live cell fluorescent imaging	Fluorescence microscopy imaging provided, both in spinning disk and confocal mode, on living cells. This also includes functional imaging to understand protein behavior. The facility specialises in tracking fast protein dynamics and interactions, particularly in DNA repair.	EURO-BIOIMAGING	Advanced Light Microscopy Node Sofia Bulgaria	1 user project	https://www.eurobioimaging.eu/nodes/sofia-bioimaging-node---advanced-light-microscopy-node-sofia-bulgaria
2.12b+2.33b+2.40b_LM Super	CZ	LM Super-resolution and confocal microscopy	A variety of different light microscopy methods are available individually or in combination. These methods include functional imaging with fluorescence microscopy, a particular focus on super-resolution imaging using specifcially STED and SIM to reach higher resolution compared to what is available using standard methods. These methods also include mesoscopic imaging via lightsheet, high-speed imaging, second-harmonics generation and other specialised light microscopy methods	EURO-BIOIMAGING	Advanced Light and Electron Microscopy Node Prague CZ	Hour	https://www.eurobioimaging.eu/nodes/advanced-light-and-electron-microscopy-node-prague-cz
2.42d_LM Live Cell	CZ	LM Live cell QPI	Quantitative Phase Imaging of living cells is a label-free light microscopy method to retrieve the phase information of light passing through the cell, and via this determine dry mass of the cell, its changes over time, and track cellular behavior over time. Due to the label free nature of the imaging, it can be applied to unstained samples, including patient biopsies. It is a gentle imaging method with little photodamage and can be applied to living cells over time.	EURO-BIOIMAGING	Advanced Light and Electron Microscopy Node Prague CZ	hour	https://www.eurobioimaging.eu/nodes/advanced-light-and-electron-microscopy-node-prague-cz
2.14b_EM 3D Methods	CZ	EM 3D methods	Volume EM methods are used to gain insights into ultrastructural organisation of biological samples at a sub-cellular level over a 3D volume of tissue. This can be applied to different tissues samples using various sample preparation methods. Specifically offered volume EM methods are serial-section TEM, serial blockface SEM, and FIB-SEM (Focussed Ion Beam Scanning Electron Microscopy).	EURO-BIOIMAGING	Advanced Light and Electron Microscopy Node Prague CZ	hour	https://www.eurobioimaging.eu/nodes/advanced-light-and-electron-microscopy-node-prague-cz
2.14c_EM Routine	CZ	EM routine TEM	Standard transmission electron microscopy methods to gain ultrastructural insights into subcellular organisation. The service includes different sample preparation methods, such as cryo-EM and resin-EM, and a variety of labelling methods to localise specific molecules within a sample.	EURO-BIOIMAGING	Advanced Light and Electron Microscopy Node Prague CZ	hour	https://www.eurobioimaging.eu/nodes/advanced-light-and-electron-microscopy-node-prague-cz
2.12c+2.33c+2.40c_CELLIM	CZ	Fluorescence Microscopy	Service provides access and support for a variety of light microscopy methods, specifically functional imaging with fluorescence microscopy, super-resolution imaging via single molecule localisation microscopy (SMLM) and structured illumination microscopy (SIM), mesoscopic imaging via lightsheet, expansion microscopy and other specialised light microscopy methods	EURO-BIOIMAGING	Advanced Light Microscopy and Medical Imaging Node Brno CZ	hour	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-and-medical-imaging-node-brno-cz
2.15d+2.46d_Albira	CZ	Preclinical PET-CT and SPECT-CT imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Centre for Advanced Preclinical Imaging	hour	https://www.eurobioimaging.eu/nodes/center-for-advanced-preclinical-imaging-capi
2.15e+2.46e_Xtreme Optical	CZ	In vivo optical imaging	In vivo preclinical optical Imaging, for visualizing and characterizing tumors and for imaging guided surgery. Fluorescence, bioluminescence and other optical imaging techniques are available. A variety of bioluminescent and/or fluorescent probes can be used, each targeted to a specific tissue or molecular or cellular event. Animal model preparation, probes and image data processing and analysis are included in the service.	EURO-BIOIMAGING	Centre for Advanced Preclinical Imaging	hour	https://www.eurobioimaging.eu/nodes/center-for-advanced-preclinical-imaging-capi
2.15f+2.46f_VEVO US	CZ	Preclinical UltraSound imaging	UltraSound Imaging of animal models for visualizing and quantifying tumors, allowing staging, monitoring of therapeutic treatments, or guided injection of drugs. The use of targeting microbubbles as US contrast agents allows the visualization and quantification of specific tumor biomarkers as well. The service includes animal model preparation, probes, image data processing and analysis.	EURO-BIOIMAGING	Centre for Advanced Preclinical Imaging	hour	https://www.eurobioimaging.eu/nodes/center-for-advanced-preclinical-imaging-capi
2.15g+2.46g_7T MRI	CZ	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents (with possibility of custom synthesis of specific targeting and/or theranostic probes if needed), image data processing and analysis.	EURO-BIOIMAGING	Centre for Advanced Preclinical Imaging	complete access	https://www.eurobioimaging.eu/nodes/center-for-advanced-preclinical-imaging-capi
2.12d+2.33d+2.40d+2.13a+2.41a_EMBL	DE	Fluorescence Microscopy	Different fluorescence microscopy methods are offered including expertise in project development and image analysis. The offered methods include advanced super-resolution microscopy techniques such as single molecule localisation, STED, MINFLUX, live cell imaging, mesoscopic imaging via lightsheet, functional imaging, intravital microscopy, high-throughput imaging and correlative techniques.	EURO-BIOIMAGING	EMBL-Node	hour	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-facility-embl
2.14d_EMBL	DE	Electron Microscopy	Different electron microscopy methods are offered, including correlative light and electron microscopy methods (CLEM), a variety of sample preparations, including cryo-EM methods, labelling methods to localise proteins within EM samples, and volume EM methods for 3D ultrastructural investigations. VolumeEM methods offered are serial section TEM, Serial Blockface-SEM, FIB-SEM	EURO-BIOIMAGING	EMBL-Node	hour	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-facility-embl
2.12f+2.33f+2.40f_Super-resolution mic.	FI	Super-resolution Microscopy	Super-resolution methods offered to gain increased resolution insights using fluorescence microscopy beyond what is gathered using standard fluorescence methods. The offered super-resolution approaches are single-molecule localisation microscopy (PALM, STORM), structured illumination microscopy (SIM), and STED, including needed sample preparation and analysis steps.	EURO-BIOIMAGING	Finnish Advanced Microscopy Node	hour	https://www.eurobioimaging.eu/nodes/finnish-alm-node---advanced-light-microscopy-finnish-node
2.14e_Electron Mocro.	FI	Electron Microscopy	Different electron microscopy methods are offered, including labelling methods to localise proteins within EM samples, and volume EM methods for 3D ultrastructural investigations. VolumeEM methods offered are Array tomography, serial section TEM, Serial Blockface-SEM.	EURO-BIOIMAGING	Finnish Advanced Microscopy Node	hour	https://www.eurobioimaging.eu/nodes/finnish-alm-node---advanced-light-microscopy-finnish-node
2.14f_CLEM	FI	Correlative Light and Electron Microscopy	Correlative Light and Electron Microscopy combines and correlates light and electron microscopy imaging of the same sample to achieve a higher level of understanding of the sample than possible with either technique in isolation. The facilities offer expertise starting from imaging of living cells using fluorescence microscopy, up to correlation with different EM methods for ultrastructural localisation of correlated proteins of interest.	EURO-BIOIMAGING	Finnish Advanced Microscopy Node	hour	https://www.eurobioimaging.eu/nodes/finnish-alm-node---advanced-light-microscopy-finnish-node
2.13b+2.41b_Mesoscopic Imaging	FI	Mesoscopic Imaging	Mesoscopic Imaging allows imaging of larger samples, such as tissues, organoids, and small animals at high resolution. This can be combined with cleared and expanded tissues. The specific offered methods are lightsheet microscopy and optical projection tomography	EURO-BIOIMAGING	Finnish Advanced Microscopy Node	hour	https://www.eurobioimaging.eu/nodes/finnish-alm-node---advanced-light-microscopy-finnish-node
2.15h+2.46h_Fibl-MEG	FI	MagnetoEncephaloGraphy & MRI	Magnetoencephalography (MEG) measures noninvasively minute magnetic fields produced by neuronal activity of the brain. MEG (as a standalone technique or coupled with MRI) can be used for mapping functionally important regions in the brain prior to surgery and for detecting functional impairment caused by brain tumors.	EURO-BIOIMAGING	Finnish BioMedical Imaging Node	complete access	https://www.eurobioimaging.eu/nodes/finnish-biomedical-imaging-node
2.17a_PET/CT	FI	Preclinical PET-CT Imaging	Positron Emission Tomography (PET) Imaging of animal models, for monitoring function and metabolism. PET imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Finnish BioMedical Imaging Node	complete access	https://www.eurobioimaging.eu/nodes/finnish-biomedical-imaging-node
2.17b+2.15i+2.46i_SPECT/CT	FI	Preclinical SPECT-CT Imaging	Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Finnish BioMedical Imaging Node	complete access	https://www.eurobioimaging.eu/nodes/finnish-biomedical-imaging-node
2.12e+2.33e+2.40e_Multimodal	FI	Multimodal Advanced Light Microscopy	Advanced fluorescence microscopy methods include live cell imaging, functional imaging to investigate protein dynamics and interactions (FRET, FRAP, FLIM, FCCS), second harmonics generation, total internal reflection fluorecence microscopy (TIRF), and correlative techniques.	EURO-BIOIMAGING	Finnish Advanced Microscopy Node	hour	https://www.eurobioimaging.eu/nodes/finnish-alm-node---advanced-light-microscopy-finnish-node
2.12g+2.33g+2.40g_Reg.Light	FR	Regular Light Microscopy	Light Microscopy methods are offered including fluorescence and label-free techniques, functional imaging, confocal and deconvolution microscopy, to investigate cellular and sub-cellular behavior and localisations. These methods can be applied also correlatively with high-end fluorescence microscopy and electron microscopy methods	EURO-BIOIMAGING	French BioImaging Node	hour	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.12h+2.33h+2.40h	FR	High and super-resolution microscopy	Super-resolution methods including single-molecule localisation microscopy (PALM, STORM), SIM, STED, as well as methods for high resolution imaging on standard systems such as image scanning microscopy on confocal and spinning disk systems. These methods improve the resolution for the gathered data from an around 2-fold increase to very high resolution on the nm level.	EURO-BIOIMAGING	French BioImaging Node	hour	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.13c+2.41c_Longitudinal Interval	FR	Longitudinal intravital microscopy	Intravital imaging covers a range of microscopy modalities used for the long term imaging of living animal models (e.g. zebrafish larvae, mice, rats), in various organs or tissues, or as a whole for smaller models. These methods allow tracking of tissue, cellular, and even sub-cellular, behavior in a larger context of either an organ or organoid, or a whole animal. In whole animals this is done using windows, such as cranial windows and abdominal windows, to allow access to the inside of the animal	EURO-BIOIMAGING	French BioImaging Node	hour	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.13d+2.41d_Lattice Light Sheet	FR	Lattice Lightsheet Microscopy	Lattice Light Sheet Microscopy is a special lightsheet microscope where the excitation plane is very thin (<1 µm) and uniformly flat over typical cellular dimensions. The main advantages of LLSM are its intrinsic optical sectioning, fast imaging (up to 300 frames per second), low photobleaching and phototoxicity, and sub-micrometer spatial resolution over long light sheets (10–100 µm).	EURO-BIOIMAGING	French BioImaging Node	hour	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.14g_Reg. EM/TEM	FR	Electron Microscopy	Transmission Electron Microscopy and Scanning Electron Microscopy on samples prepared with different methods, such as resin-EM and cryo-EM. This also includes support for different sample labelling methods to localise proteins in the sample.	EURO-BIOIMAGING	French BioImaging Node	complete access	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.12i+2.33i+2.40i	FR	High-end confocal Microscopy	High-end and specialised confocal microscopy methods to achieve high-resolution and fast imaging with 3D resolution, including in living and fixed cells	EURO-BIOIMAGING	French BioImaging Node	complete access	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.14h_CLEM	FR	Advanced Electron Microscopy	Advanced Electron Microscopy methods, including cryo-EM sample presentation, Correlative Light and Electron Microscopy, and volume EM methods for 3D ultrastructural investigations in a larger cellular and tissue context. The available volumeEM methods are FIB-SEM, serial blockface-SEM, and serial section TEM. This also includes Correlative X-ray, light and electron microscopy imaging	EURO-BIOIMAGING	French BioImaging Node	hour	https://www.eurobioimaging.eu/nodes/french-bioimaging-node
2.12j+2.33j+2.40j_UNIDEB	HU	Advanced Light Microscopy	Advanced Light Microscopy methods, particularly fluorescence imaging methods with a specific focus on functional imaging methods to study protein interactions and dynamics (FRET, FRAP, FLIM, FCCS), as well as high-throughput imaging and light-sheet microscopy	EURO-BIOIMAGING	Cellular Imaging Hungary Node	complete access	https://www.eurobioimaging.eu/nodes/cellular-imaging-hungary
2.12k+2.33k+2.40k_Semmelweis	HU	Super-resolution	A range of microscopy techniques used to achieve a resolution that is higher than that of conventional, diffraction-limited microscopy, particularly single-molecule localisation microscopy (SMLM) and STED.	EURO-BIOIMAGING	Cellular Imaging Hungary Node	complet access	https://www.eurobioimaging.eu/nodes/cellular-imaging-hungary
2.14i_BRC CILAB	HU	Advanced Light and correlative imaging methods	Advanced Light Microscopy methods, including super-resolution and functional imaging, in combination and correlation with Electron Microscopy approaches and methods for sample characterisation.	EURO-BIOIMAGING	Cellular Imaging Hungary Node	complete access	https://www.eurobioimaging.eu/nodes/cellular-imaging-hungary
2.12l+2.33l+2.40l_FEMTO	HU	Two-photon Microscopy	Multiphoton microscopy - most commonly in the form of two-photon microscopy - is a fluorescence imaging technique that allows observation of living tissue up to about one millimeter in depth.	EURO-BIOIMAGING	Cellular Imaging Hungary Node	complete access	https://www.eurobioimaging.eu/nodes/cellular-imaging-hungary
2.15j+2.46j	HU	Preclinical PET Imaging and Autoradiography	Positron Emission Tomography (PET) Imaging of animal models, for monitoring function and metabolism. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Medical and Preclinical Imaging Hungary	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
2.17c_SCANOMED	HU	Preclinical PET-CT and SPECT-CT imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Medical and Preclinical Imaging Hungary	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
2.15k+2.46k+2.17d_Semmelweis	HU	Preclinical PET-CT and SPECT-CT imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Medical and Preclinical Imaging Hungary	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
2.15l+2.46l_UP,SzRC	HU	In vivo Optical Imaging	In vivo preclinical optical Imaging, for visualizing and characterizing tumors and for imaging guided surgery. Fluorescence, bioluminescence and other optical imaging techniques are available. A variety of bioluminescent and/or fluorescent probes can be used, each targeted to a specific tissue or molecular or cellular event. Animal model preparation, probes and image data processing and analysis are included in the service.	EURO-BIOIMAGING	Medical and Preclinical Imaging Hungary	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
2.15m+2.46m_Biospec	IL	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents (with possibility of custom synthesis of specific targeting and/or theranostic probes if needed), image data processing and analysis.	EURO-BIOIMAGING	Israel BioImaging	Shift (4 hours)	https://www.eurobioimaging.eu/nodes/israel-bioimaging
2.12m+2.33m+2.40m_Ultramicro	IL	Super-resolution	A range of microscopy techniques used to achieve a resolution that is higher than that of conventional, diffraction-limited microscopy, specifically as single-molecule localisation microscopy (SMLM) and STED.	EURO-BIOIMAGING	Israel BioImaging	hour
2.19a,2.42a_VBCF	AT	low-resolution Mass Spectrometry based Imaging	Surface analysis techniques which are based on desorption and ionization of molecules followed by their subsequent MS data recording. After collecting a mass spectrum at one spot, the sample is moved to the neighboring spot, and the mass spectrum is sampled again, until the entire sample surface is scanned	EURO-BIOIMAGING	Austrian BioImaging	Hour	https://www.eurobioimaging.eu/nodes/austrian-bioimagingcmi
2.32a_HCS	IL	High-content screening	Using automated cell manipulations and microscopy platforms, high-content screening can range from entire genomes screens and high-content analysis, to slide scanning of a large number of tissue biopsy sections. HCS techniques rely on fully automated widefield or confocal microscopy systems which facilitate the capture of thousands of images, often in multi-well plates or on slides.	EURO-BIOIMAGING	Israel BioImaging	day	https://www.eurobioimaging.eu/nodes/israel-bioimaging
2.15n+2.46n_in vivo optic.imag.	IL	In vivo Optical Imaging	In vivo preclinical optical Imaging, for visualizing and characterizing tumors and for imaging guided surgery. Fluorescence, bioluminescence and other optical imaging techniques are available. A variety of bioluminescent and/or fluorescent probes can be used, each targeted to a specific tissue or molecular or cellular event. This service makes use of an Olympus optical system. Animal model preparation, probes and image data processing and analysis are included in the service.	EURO-BIOIMAGING	Israel BioImaging	hour	https://www.eurobioimaging.eu/nodes/israel-bioimaging
2.15o+2.46o_in vivo optic. imag.	IL	In vivo Optical Imaging	In vivo preclinical optical Imaging, for visualizing and characterizing tumors and for imaging guided surgery. Fluorescence, bioluminescence and other optical imaging techniques are available. A variety of bioluminescent and/or fluorescent probes can be used, each targeted to a specific tissue or molecular or cellular event. This service makes use of a Spektrum IVIS optical system. Animal model preparation, probes and image data processing and analysis are included in the service.	EURO-BIOIMAGING	Israel BioImaging	hour	https://www.eurobioimaging.eu/nodes/israel-bioimaging
2.15p+2.46p_in vivo optic.imag	IL	In vivo Optical Imaging	In vivo preclinical optical Imaging, for visualizing and characterizing tumors and for imaging guided surgery. Fluorescence, bioluminescence and other optical imaging techniques are available. A variety of bioluminescent and/or fluorescent probes can be used, each targeted to a specific tissue or molecular or cellular event. This service makes use of an IVIS-KINETIC optical system. Animal model preparation, probes and image data processing and analysis are included in the service.	EURO-BIOIMAGING	Israel BioImaging	hour	https://www.eurobioimaging.eu/nodes/israel-bioimaging
2.12n+2.33n+2.40n_LM	IT	Light Microscopy	Light Microscopy methods are offered including fluorescence and label-free techniques, multiphoton and volumetric imaging, non-linear microscopy, functional imaging for protein dynamics and interactions, in-flow microscopy, large sample imaging in cleared and expanded samples	EURO-BIOIMAGING	Advanced Light Microscopy Italian Node	complete access	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-italian-node
2.12o+2.33o+2.40o_SR	IT	Super-resolution Microscopy	Single-molecular localisation microscopy (PALM, STORM) including both in 2D and 3D, STED, and image scanning microscopy to achieve higher resolution images compared to standard diffraction-limited microscopy	EURO-BIOIMAGING	Advanced Light Microscopy Italian Node	complete access	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-italian-node
2.14j_EM	IT	Electron Microscopy	Different electron microscopy methods, particularly as CLEM in correlation with light microscopy. The offered methods include transmission, scanning, cryo, and volume EM, such as FIB-SEM and serial section TEM.	EURO-BIOIMAGING	Advanced Light Microscopy Italian Node	complete access	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-italian-node
2.32b_HTI	IT	High-throughput Imaging	Using automated cell manipulations and microscopy platforms, high-content screening can range from entire genomes screens and high-content analysis, to slide scanning of a large number of tissue biopsy sections. HCS techniques rely on fully automated widefield or confocal microscopy systems which facilitate the capture of thousands of images, often in multi-well plates or on slides.	EURO-BIOIMAGING	Advanced Light Microscopy Italian Node	complete access	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-italian-node
2.15q+2.46q_micro PET	IT	Preclinical PET-CT imaging	Positron Emission Tomography (PET) Imaging of animal models, for monitoring function and metabolism. PET imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Digital Imaging Multimodal Platform Neuromed - DIMP NEUROMED	complete access	https://www.eurobioimaging.eu/nodes/digital-imaging-multimodal-platform-neuromed---dimp-neuromed
2.19b+2.42b_Brucker FTICR	AT	High-resolution Mass Spectrometry based Imaging	Surface analysis techniques which are based on desorption and ionization of molecules followed by their subsequent MS data recording. After collecting a mass spectrum at one spot, the sample is moved to the neighboring spot, and the mass spectrum is sampled again, until the entire sample surface is scanned	EURO-BIOIMAGING	Austrian BioImaging	Hour	https://www.eurobioimaging.eu/nodes/austrian-bioimagingcmi
2.12p+2.33p+2.40p	IT	Light Microscopy	Foundational light microscopy tools and sample preparation for immunohistochemistry on animal samples provided in concert with other preclinical imaging measures	EURO-BIOIMAGING	Digital Imaging Multimodal Platform Neuromed - DIMP NEUROMED	complete access	https://www.eurobioimaging.eu/nodes/digital-imaging-multimodal-platform-neuromed---dimp-neuromed
2.15r+2.46r_Population imag.	IT	Population imaging	Application of advanced image analysis tools to large numbers of medical images related to population cohorts for the identification and monitoring of specific imaging biomarkers which can provide information about diseases at the population level, allowing early diagnosis, early identification of people at risk and preventive measures.	EURO-BIOIMAGING	Digital Imaging Multimodal Platform Neuromed - DIMP NEUROMED	complete access	https://www.eurobioimaging.eu/nodes/digital-imaging-multimodal-platform-neuromed---dimp-neuromed
2.17e_Phase Contrast	IT	Phase Contrast X-ray Imaging	In respect to other x-rays based imaging techniques, Phase Contrast X-ray Imaging (PCI) is useful for imaging soft tissues that do not possess large variations in X-ray absorption properties. Phase Contrast Imaging can also be combined with tomographic techniques to obtain 3D reconstruction. Image data processing and analysis included in the service.	EURO-BIOIMAGING	Phase Contrast Imaging Flagship Node Trieste	Hour	https://www.eurobioimaging.eu/nodes/phase-contrast-imaging-flagship-node-trieste
2.15s+2.46s_MRI	IT	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents (with possibility of custom synthesis of specific targeting and/or theranostic probes if needed), image data processing and analysis.	EURO-BIOIMAGING	MultiModal Molecular Imaging Italian Node	complete access	https://www.eurobioimaging.eu/nodes/molecular-imaging-italian-node
2.15t+2.46t_PET/SPECT	IT	Preclinical PET-CT and SPECT-CT imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	MultiModal Molecular Imaging Italian Node	complete access	https://www.eurobioimaging.eu/nodes/molecular-imaging-italian-node
2.17f_CT_MMMI 3	IT	Preclinical X-Rays Computed Tomography	X-rays Computed Tomography (CT) makes use of X-ray images (projections) taken from different angles and image reconstruction techniques to produce high resolution anatomic cross-sectional (tomographic) 3D images. CT contrast agents (usually based on Iodine, Barium, Gold) can be used to enhance the contrast. Preclinical microCT systems can be stand alone or integrated with other modalities like optical or nuclear medicine imaging in order to perform multimodal imaging.	EURO-BIOIMAGING	MultiModal Molecular Imaging Italian Node	complete access	https://www.eurobioimaging.eu/nodes/molecular-imaging-italian-node
2.34a	IT	Preclinical Photocoustic imaging	Photoacoustic Imaging (PAI) of animal models, combining the advantages of optical and US imaging technologies. The US signal makes it possible to achieve an increase of both spatial resolution (micrometric) and penetration depth with respect to optical imaging and reduces scattering phenomena. In comparison with US a wider range of molecules can be used as PAI contrast agents. PAI allows to get 3D-high resolution images of soft tissues which provide anatomical, functional, and molecular information. The service includes animal model preparation, probes and image data processing and analysis.	EURO-BIOIMAGING	MultiModal Molecular Imaging Italian Node	complete access	https://www.eurobioimaging.eu/nodes/molecular-imaging-italian-node
2.14k_Light fluorescence	NL	Light and Fluorescence Microscopy	Light Microscopy methods, including fluorescence microscopy in deconvolution widefield, confocal and spinning disk mode, functional imaging such as FLIM, FRET, FRAP and FCCS to measure protein dynamics and interactions	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.12q+2.33q+2.40q_Spectral fluor.	NL	Multispectral Imaging	Mulitspectral Imaging allows the simultaneous detection mulitple biomarkers in tissues at the same time within a sample, including when they are co-localised. This is especially applicable for tissue section and biopsies where samples are rare and individual can be simultaneously stained with many markers to extract maximum information from individual samples.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.12r+2.33r+2.40r	NL	Super-resolution Microscopy	Super-resolution microscopy, specifically in the form of STED microscopy, for increased resolution compared to standard diffraction-limited microscopy	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.42c_ATI XRayLab	AT	Micro X-ray Fluorescence Spectrometry	Micro-X-Ray Fluorescence Spectrometry (XRF) allows the qualitative analysis of the elemental composition of solid samples. The detected signal results from the emission of element-characteristic fluorescence X-rays from a sample bombarded with high-energy X-rays	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	Week	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.13e+2.41e_Light fluor.	NL	Two-photon microscopy	Multiphoton microscopy - most commonly in the form of two-photon microscopy - is a fluorescence imaging technique that allows observation of living tissue up to about one millimeter in depth.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14l	NL	Transmission Electron Microscopy	In transmission electron microscopy (TEM) the accelerated beam of electrons is transmitted through the sample and collected to form an image. To achieve this the specimen is usually sectioned into ultrathin sections less than 100 nm thick. Different methods for sample preparation are available	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14m	NL	Cryo-Transmission Electron Microscopy	In transmission electron microscopy (TEM) the accelerated beam of electrons is transmitted through the sample and collected to form an image. To achieve this the specimen is usually sectioned into ultrathin sections less than 100 nm thick. Here specifically samples are cryo-fixed, either through plunge freezing for very small samples or via high-pressure freezing	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14n	NL	Scanning Electron Microscopy	Scanning electron microscopy describes a mode of electron microscopy in which the beam of accelerated electrons is scanned along the surface of the sample to gather insights into the surface structure at nanometer resolution. This can be applied to either whole samples or sections.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14o_DualBeam	NL	Dual Beam Scanning Electron Microscopy	Scanning electron microscope with a dual beam set up allowing for faster data acquisition in scanning electron microscopy mode.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.19c+2.42e_SOLARIX	NL	Mass-Spectrometry based Imaging using SOLARIX	Surface analysis techniques which are based on desorption and ionization of molecules followed by their subsequent MS data recording. After collecting a mass spectrum at one spot, the sample is moved to the neighboring spot, and the mass spectrum is sampled again, until the entire sample surface is scanned. Here performed via SOLARIX.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	Hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.19d+2.42f_RAPIFLEX	NL	Mass-Spectrometry based Imaging RAPIFLEX	Surface analysis techniques which are based on desorption and ionization of molecules followed by their subsequent MS data recording. After collecting a mass spectrum at one spot, the sample is moved to the neighboring spot, and the mass spectrum is sampled again, until the entire sample surface is scanned. Here performed via SOLARIX.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	Hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.32c	NL	Mass-Spectrometry based Imaging using HTX	Surface analysis techniques which are based on desorption and ionization of molecules followed by their subsequent MS data recording. After collecting a mass spectrum at one spot, the sample is moved to the neighboring spot, and the mass spectrum is sampled again, until the entire sample surface is scanned. Here performed via HTX	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.13f_LEICA	NL	Light Microscopy	Light Microscopy methods, specifcally label-free techniques, to investigate cellular and sub-cellular behavior and localisations	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.15u+2.46u_PET/SPECT	NL	Preclinical PET and SPECT imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	complete access	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14a_HREM	AT	High-resolution Episcopic microscopy	High-resolution Episcopic microscopy or Serial block face fluorescence imaging is a method used to generate 3-dimensional (3D) reconstruction of a sample via serial image acquisition, here on a microtome, using light microscopy imaging techniques.	EURO-BIOIMAGING	Austrian BioImaging	hour	https://www.eurobioimaging.eu/nodes/austrian-bioimagingcmi
2.17f_CT	NL	Preclinical X-Rays Computed Tomography	X-rays Computed Tomography (CT) on tissues, organs or living animal models. CT contrast agents (usually based on Iodine, Barium, Gold) can be used to enhance the contrast. Preclinical microCT systems can be stand alone or integrated with other modalities like optical or nuclear medicine imaging in order to perform multimodal imaging. The service includes animal model prepartion, contrast agents if needed, image data processing and analysis.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	complete access	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.15v+2.46v_in vivo optic.imag	NL	In vivo Optical Imaging	In vivo preclinical optical Imaging, for visualizing and characterizing tumors and for imaging guided surgery. Fluorescence, bioluminescence and other optical imaging techniques are available. A variety of bioluminescent and/or fluorescent probes can be used, each targeted to a specific tissue or molecular or cellular event. Animal model preparation, probes and image data processing and analysis are included in the service.	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	complete access	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14p_Electron microsc.	NL	Electron Microscopy Sample preparation support	Support with both the selection of the most appropriate sample preparation technique for different Electron Microscopy investigations, trouble-shooting of protocols and practical sample preparation support	EURO-BIOIMAGING	Facility of MultiModal Imaging, AMMI Maastricht	hour	https://www.eurobioimaging.eu/nodes/facility-of-excellence-in-imaging---alm-and-molecular-imaging-node-maastricht
2.14q_Dutch CLEM	NL	Correlative Light and Electron Microscopy	A wide variety of electron microscopy methods, including correlative light and electron microscopy (CLEM) is available. The EM methods include different vEM modalities, such as Array Tomography, FIB-SEM, serial blockface SEM and serial section TEM. Different methods for sample prepartion inlcuding chemical and cryo-fixation, and labelling of proteins of interest in EM sample are available. The service also includes Elemental analysis via EDX.	EURO-BIOIMAGING	Dutch CLEM Node	complete access	https://www.eurobioimaging.eu/nodes/correlative-light-microscopy-dutch-flagship-node
2.15w+2.46w	NL	High Field Magnetic Resonance Imaging (human)	Human high field Magnetic resonance imaging (MRI), comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. MRI scanners at high magnetic fields have the advantage to significantly increase the sensitivity and thus improve the image resolution and scan duration. This service is provided on a 7T scanner.	EURO-BIOIMAGING	Dutch High Field MR Hub	complete access	https://www.eurobioimaging.eu/nodes/dutch-high-field-imaging-hub
2.15x+2.46x_HF MRI	NL	High Field Magnetic Resonance Imaging (human)	Human high field Magnetic resonance imaging (MRI), comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. MRI scanners at high magnetic fields have the advantage to significantly increase the sensitivity and thus improve the image resolution and scan duration. This service is provided on a 9.4T scanner.	EURO-BIOIMAGING	Dutch High Field MR Hub	complete access	https://www.eurobioimaging.eu/nodes/dutch-high-field-imaging-hub
2.15y+2.46y	NL	High Field Magnetic Resonance Imaging (human)	Human high field Magnetic resonance imaging (MRI), comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. MRI scanners at high magnetic fields have the advantage to significantly increase the sensitivity and thus improve the image resolution and scan duration. This service is provided on a 7T scanner.	EURO-BIOIMAGING	Dutch High Field MR Hub	complete access	https://www.eurobioimaging.eu/nodes/dutch-high-field-imaging-hub
2.15z+2.46z_MRI	NL	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents, image data processing and analysis.	EURO-BIOIMAGING	Preclinical Imaging Centre	Hour	https://www.eurobioimaging.eu/nodes/preclinical-imaging-centre-(prime)---molecular-imaging-dutch-node
2.12s+2.33s+2.40s_NorMIC	NO	Advanced Light Microscopy and standard Electron Microscopy	Advanced Light Microscopy Imaging, including confocal, super-resolution microscopy through SIM or single-molecule localisation, functional imaging for protein dynamics and interactions (FRET, FRAP), TIRF, and live-cell imaging and high-speed imaging.	EURO-BIOIMAGING	Advanced Light Microscopy Node Oslo - NorMIC	hour	https://www.eurobioimaging.eu/nodes/normic-oslo---advanced-light-microscopy-node-oslo
2.15aa+2.46aa_NORMOLIM	NO	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents, image data processing and analysis.	EURO-BIOIMAGING	NORMOLIM - Norwegian Molecular Imaging Infrastructure	hour	https://www.eurobioimaging.eu/nodes/normolim,-norwegian-molecular-imaging-infrastructure
2.15a+2.46a_Inveon	AT	Preclinical PET-CT and SPECT-CT imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Austrian BioImaging	hour	https://www.eurobioimaging.eu/nodes/austrian-bioimagingcmi
2.15ab+2.46ab_NORMOLIM	NO	Preclinical PET imaging	Positron Emission Tomography (PET) Imaging of animal models, for monitoring function and metabolism. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	NORMOLIM - Norwegian Molecular Imaging Infrastructure	hour	https://www.eurobioimaging.eu/nodes/normolim,-norwegian-molecular-imaging-infrastructure
2.15ac+2.46ac_NORMOLIM	NO	Preclinical UltraSound imaging	UltraSound Imaging of animal models for visualizing and quantifying tumors, allowing staging, monitoring of therapeutic treatments, or guided injection of drugs. The use of targeting microbubbles as US contrast agents allows the visualization and quantification of specific tumor biomarkers as well. The service includes animal model preparation, probes, image data processing and analysis.	EURO-BIOIMAGING	NORMOLIM - Norwegian Molecular Imaging Infrastructure	hour	https://www.eurobioimaging.eu/nodes/normolim,-norwegian-molecular-imaging-infrastructure
2.12t+2.33t+2.40t_ALM	PL	Advanced Light Microscopy	Advanced Light Microscopy Imaging, including confocal, super-resolution microscopy through SIM, STED or single-molecule localisation, functional imaging for protein dynamics and interactions (FRET, FRAP, FLIM, FCCS), TIRF, microdissection and two-photon microscopy.	EURO-BIOIMAGING	Advanced Light Microscopy Node Poland	hour	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-node-poland
2.14r_ALM	PL	Electron Microscopy	A range of Electron Microscopy techniques are available, including SEM, TEM, volumeEM in the form of serial section TEM, and Eletron tomography. This also includes methods for labelling proteins of interest in EM samples	EURO-BIOIMAGING	Advanced Light Microscopy Node Poland	Hour	https://www.eurobioimaging.eu/nodes/advanced-light-microscopy-node-poland
2.15ad+2.46ad_MRI	PT	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. The service includes animal model preparation, provision of contrast agents, image data processing and analysis.	EURO-BIOIMAGING	Brain Imaging Network	hour	https://www.eurobioimaging.eu/nodes/brain-imaging-network-bin
2.12u+2.33u+2.40u_Instituto	PT	Advanced Light Microscopy and Electron Microscopy	Different fluorescence microscopy methods are offered including expertise in project development and image analysis. The offered methods include super-resolution microscopy techniques such as single molecule localisation, STED, SIM, live cell imaging, mesoscopic imaging via lightsheet and optical projection tomography, functional imaging (FRET, FRAP, FLIM, FCCS), intravital microscopy, high-throughput imaging and correlative techniques. This also includes support techniques such as expansion microscopy, tissue clearing and microdissection	EURO-BIOIMAGING	Portuguese Platform of BioImaging PPBI	hour	https://www.eurobioimaging.eu/nodes/portuguese-platform-of-bioimaging-ppbi
2.14s	SE	Electron Microscopy	Electron Microscopy techniques, including SEM, TEM, volumeEM, and Eletron tomography. Volume EM methods available include array tomography, serial section TEM, and FIB-SEM. This also includes support for correlative methods and different sample preparations, such as chemical and cryo-fixation. Different methods for labelling proteins of interest in EM are available. Various cryo-EM methods can also be requested	EURO-BIOIMAGING	Swedish National Microscopy Infrastructure	hour	https://www.eurobioimaging.eu/nodes/swedish-national-microscopy-infrastructure-nmi
2.12v+2.33v+2.40v+2.13j+2.41j_NMI	SE	Advanced Light Microscopy	Advanced Light Microscopy methods, including super-resolution (SMLM, STED, SIM) and functional imaging (FRET, FLIM, FRAP, FCCS), intravital microscopy, mesoscopic imaging with lightsheet, lattice lightsheet, feedback microscopy, expansion microscopy and other specialised and support methods.	EURO-BIOIMAGING	Swedish National Microscopy Infrastructure	hour	https://www.eurobioimaging.eu/nodes/swedish-national-microscopy-infrastructure-nmi
2.25a_LIP	FR	Molecular profiling of a patient-derived xenograft (PDX) model.	Generation of molecular profiles (e.g., DNA-seq, RNA-seq, Immunohistochemistry, others) on a PDX model, either provided by the user or selected from the EurOPDX collection. The standard service (1x Unit of Access) involves generating one type of profile on one sample. To perform more complex studies, more units of access must be selected. For instance, for a combined DNA-seq/RNA-seq profiling two Units of access are required. The service can be combined with drug efficacy testing, e.g., to profile PDXs after in vivo treatment.	UNITO	Institut Curie	1 PDX model	https://dataportal.europdx.eu/
2.25b_MCCA	NL	Molecular profiling of a patient-derived xenograft (PDX) model.	Generation of molecular profiles (e.g., DNA-seq, RNA-seq, Immunohistochemistry, others) on a PDX model, either provided by the user or selected from the EurOPDX collection. The standard service (1x Unit of Access) involves generating one type of profile on one sample. To perform more complex studies, more units of access must be selected. For instance, for a combined DNA-seq/RNA-seq profiling two Units of access are required. The service can be combined with drug efficacy testing, e.g., to profile PDXs after in vivo treatment.	UNITO	Netherlands Cancer Institute	1 PDX model	https://dataportal.europdx.eu/
2.30a_LIP	FR	In vivo drug efficacy testing on a selected patient-derived xenograft (PDX) model.	Performance of an in vivo drug efficacy study on a selected patient-derived xenografts (PDX) model. The standard service (1x Unit of Access) consists in testing a user-provided drug or compound in a 2-arms study, one control arm and one treatment arm, with 6 NSG mice/arm, and includes a prior tolerability study (3 NSG mice/arm). To perform more complex studies, more units of access must be selected. For instance, for a 4 arms study (e.g., vehicle arm; drug A arm; drug B arm; drug A + drug B arm), two units of access are required. The user could select the PDX model on the EurOPDX Data Portal (https://dataportal.europdx.eu/), supported by the Research Infrastructure. The costs for shipment or, in case, for buying commercial drug(s) or compound(s) to be used in the study are not included in the service.	UNITO	Institut Curie	1 PDX model	https://dataportal.europdx.eu/
2.30b_MCCA	NL	In vivo drug efficacy testing on a selected patient-derived xenograft (PDX) model.	Performance of an in vivo drug efficacy study on a selected patient-derived xenografts (PDX) model. The standard service (1x Unit of Access) consists in testing a user-provided drug or compound in a 2-arms study, one control arm and one treatment arm, with 6 NSG mice/arm, and includes a prior tolerability study (3 NSG mice/arm). To perform more complex studies, more units of access must be selected. For instance, for a 4 arms study (e.g., vehicle arm; drug A arm; drug B arm; drug A + drug B arm), two units of access are required. The user could select the PDX model on the EurOPDX Data Portal (https://dataportal.europdx.eu/), supported by the Research Infrastructure. The costs for shipment or, in case, for buying commercial drug(s) or compound(s) to be used in the study are not included in the service.	UNITO	Netherlands Cancer Institute	1 PDX model	https://dataportal.europdx.eu/
2.31b_MEDINA	ES	Advanced profiling services including in-vitro efficacy, toxicological, ADME, stability, PK and PD investigations of confirmed hit compounds	ADME-TOX studies platform include drug metabolism studies (CYP inhibition (6 isoforms)and CYP induction, drug metabolites identification, metabolic stability (hepatocytes and liver microsomes), plasma protein binding, plasma stability, reactive metabolite assessment),bioanalysis and PK analysis, drug absorption PAMPA, physicochemical profiling ( thermodynamic solubility, chemical and kinetic stability), toxicity ( cytotoxicity, cardiotoxicity, genotoxicity AMES and Micronucleus test, neurotoxicity)	EU-OPENSCREEN	Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía	ADME-tox panel of assays (for 10 compounds)	https://www.medinadiscovery.com/ https://www.es-openscreen.com/partner/fundacion-medina/
2.31c_SINTEF	NO	Advanced profiling services including in-vitro efficacy, toxicological, ADME, stability, PK and PD	Advanced profiling services including in-vitro efficacy, toxicological, ADME, stability, PK and PD investigations of confirmed hit compounds	EU-OPENSCREEN	SINTEF	in-vitro immunotox.	https://www.sintef.no
2.32a_USC	ES	High-content image-based profiling of compounds and high-throughput microscopy services, including those applied on patient-derived cells	The INNOpharma Screening platform has state-of-the-art equipment for screening campaigns with different technological approaches.	EU-OPENSCREEN	University of Santiago de Compostela	1-month project ( HCS compound prof)	https://www.usc.gal/en/department/pharmacology-pharmacy-and-pharmaceutical-technology
2.32b_ITMP	DE	High-content image-based profiling of compounds and high-throughput microscopy services, including those applied on patient-derived cells	Establisihing assays and screening for viability, proliferation and multi-parametric high-content microscopy readouts and profiling batches of up to 50 compounds.	EU-OPENSCREEN	Fraunhofer Institute for Translational Medicine and Pharmacology	compound profiling	https://www.itmp.fraunhofer.de/
2.32c_MEDINA	ES	High-content image-based profiling of compounds and high-throughput microscopy services, including those applied on patient-derived cells	Fully integrated fluorescence imaging platform and associated software for bio-imaging assays with primary and established cell lines; multiparametric high content imaging with broad range of target-based and phenotype-based assays (kinetic or single endpoint live-cells analysis; broad fluorophore choice for multiplexing); customized project from experimental approach to data analysis. Determination cell toxicity effects, cell functions, cell signaling pathways , cell structures and morphological features	EU-OPENSCREEN	Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía	compound profiling (for 10 compounds)	https://www.medinadiscovery.com/ https://www.es-openscreen.com/partner/fundacion-medina/
2.35_MEDINA	ES	Validation of the binding affinity and kinetics of compounds towards the drug target via biophysical methods, e.g., SPR, ITC, DSF	Application of biophysical methods to determine the binding affinity and binding kinetics of compounds to the selected target	EU-OPENSCREEN	Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía	DSF analysis (for 10 compounds)	https://www.medinadiscovery.com/ https://www.es-openscreen.com/partner/fundacion-medina/
2.31a_CIPF	ES	Advanced profiling services including in-vitro efficacy, toxicological, ADME, stability, PK and PD investigations of confirmed hit compounds	Validation assays to support hit identification ranging from cell to molecular biology and adapting to the applicat request. Alternatively, in-vivo assays in wild type mice for 1 candidate + control group could be performed to determine PK studies by LC-MS or toxicological studies by biochemical markers and histology of major organs. Intravenous adminisration, subcutaneous, intraasal, intraperitoneal or oral administration could be performed.	EU-OPENSCREEN	Centro de Investigación Príncipe Felipe	validation assay	http://www.VicentResearchLab.com
2.29b_MEDINA	ES	Consultation and support in the development of disease-relevant biochemical, pathway-based and cell-based 2D or 3D assays for compound screening or hit validation	Expert assessment and technical support in the development and miniaturization of new biochemical and phenotypic assays to be run in high throughput screening platforms for hit discovery and hit validation follow-up	EU-OPENSCREEN	Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía	Hour of consult	https://www.medinadiscovery.com/ https://www.es-openscreen.com/partner/fundacion-medina/
2.29a_CIPF	ES	Consultation and support in the development of disease-relevant biochemical, pathway-based and cell-based 2D or 3D assays for compound screening or hit validation	Advise to be given by phone or by email or by TC/VC, in any doubt concerning the stablishment and use of 2D and 3D based phenotypic assays. Homospheroids, heterospheroids or organoids from commercially available cell lines or patient derived. As well as any adequate confirmation assays for hit validation.	EU-OPENSCREEN	Centro de Investigación Príncipe Felipe	hour of consultation	http://www.VicentResearchLab.com
2.6_I2PC_EM	ES	Electron Microscopy Image Analysis, I2PC, Madrid, Spain - canSERV	This platform will provide personalised support to projects requiring specialised processing of either electron or X-ray microscopy images. It will also help developers in integrating their methods into generally accessible analysis workflows. The Instruct Image Processing Centre (I2PC) in Madrid will assign personnel to this analysis, as well as the required computational resources.	INSTRUCT-ERIC	Instruct Centre ES - Instruct Image Processing Centre	1day
2.5+2.22+2.47_Instruct	CZ	Electron Microscopy, Brno, Czech Republic - canSERV	Access to state-of-the-art instrumentation for electron cryo-microscopy and user support in sample preparation, data acquition, and data processing. Services include high-throughput single particle analysis (SPA) data collection, cryo-electron tomography data acquisition, cryo-FIB lamella preparation, electron diffraction tomography (micro-ED) data acquisition, data analysis, sample preparation and cryo-EM screening, resin embedding, FIB-SEM tomography.	INSTRUCT-ERIC	Instruct Centre CZ - CEITEC	1 day	https://www.ceitec.eu
2.10+2.19_instruct	FI	X-ray Diffraction, Oulu, Finland - canSERV	Biocenter Oulu Protein Crystallography core facility offers crystallization using nanoliter dispensers and a collection of commercial and self maintained crystallization screens. Crystallization is followed using the IceBear software and remote access to monitor the experiments can be provided following the visit. Biocenter Oulu Protein Crystallography core facility further offers home-source X-ray generator for macromolecular crystal diffraction experiments.	INSTRUCT-ERIC	Instruct Centre FI - University of Oulu	1 day
2.4+2.39_Instruct	CZ	Protein Production, Vestec near Prague, Czech Republic - canSERV	The core facility for protein production provides services covering DNA cloning and DNA plasmid preparation, protein expression in E. coli expression systems and recombinant protein purification. Our services can also include optimization of expression and purification protocols, protein identity and purity testing and determination of protein concentration.	INSTRUCT-ERIC	Instruct Centre CZ - BIOCEV	1 day	https://www.biocev.eu
2.45_Instruct	NL	PDB-REDO, Amsterdam, Netherlands - canSERV	PDB-REDO is a procedure to optimise crystallographic structure models, providing algorithms that make a fully automated decision making system for refinement, rebuilding and validation. With PDB-REDO you can obtain updated and optimised versions of existing entries of the PDB from our DataBank, or you can optimise your own structure model using our Server. Due to robust automation, the procedure can be run at scales from individual structures to high-throughput optimization of thousands of structures. If you want to know more, please check https://pdb-redo.eu	INSTRUCT-ERIC	Instruct Centre NL - Netherlands Cancer Institute	1 day	https://www.nki.nl/research/facilities-platforms/protein-facility/
2.7+2.19+2.23+2.37_Instruct	CZ	Solution NMR, Brno, Czech Republic - canSERV	The Core Facility of High Field NMR Spectroscopy at CEITEC Instruct centre provides access to NMR spectrometers in the range of proton frequencies from 500 MHz to 950 MHz. The equipment is suited mainly to the studies of structure, dynamics and interactions of biomolecules, i.e. proteins, nucleic acids and carbohydrates. However, the instrumentation is flexible enough to cover various research needs in material science, organic and inorganic chemistry, biochemistry, biology and biophysics.	INSTRUCT-ERIC	Instruct Centre CZ - CEITEC	1 day	https://www.ceitec.eu
2.3+2.21+2.38_Instruct	BE	Nanobody Services, Brussels, Belgium - canSERV	This service includes the generation and characterisation of conformational nanobodies (to facilitate the structural analysis of proteins that are notoriously difficult to purify, to crystallize or to study by another method), as well as rapid selection of nanobodies by screening/affinity maturation. Nanobodies can also be functionally expressed as intrabodies in eukaryotic cells, therefore these single-domain antibodies can also be used to track their targets inside a living cell.	INSTRUCT-ERIC	Instruct Centre BE - Nanobodies4Instruct	1 day	https://www.steyaertlab.be
2.8+2.20+2.23+2.35_Instruct	CZ	Native Mass Spectrometry and Molecular Biophysics, Vestec near Prague, Czech Republic - canSERV	Services include various methodologies for the characterisation of protein structures, identification and quantification of proteins, precise determination of protein molecular mass, characterisation of post translational modifications, analysis of kinetic and thermodynamic parameters of biomolecular interactions, and biophysical characterisation of the structure, function and stability of biological macromolecules like proteins, nucleic acids, lipids and their complexes. The service provided includes data processing and reporting ready for publication.	INSTRUCT-ERIC	Instruct Centre CZ - BIOCEV	1 day	https://www.biocev.eu
2.9+2.36_Instruct	FR	CrystalDirect Automated Fragment Screening Pipeline, EMBL, Grenoble - canSERV	EMBL Grenoble offers access to a fully automated protein to structure pipeline based on the CrystalDirect technology and the Crystallization Information Management System (CRIMS) software. The CrystalDirect technology enables automated crystal soaking making it possible to support automated, large scale small molecule and Fragment Screening through crystallography efficiently and in a short time.	INSTRUCT-ERIC	Instruct Centre EMBL - EMBL Grenoble	1 day	www.embl.fr/services/index.html
*NEW 2.15f + 2.46f_VEVO US_a	CZ	Preclinical Photocoustic imaging	Photoacoustic Imaging (PAI) of animal models, combining the advantages of optical and US imaging technologies. The US signal makes it possible to achieve an increase of both spatial resolution (micrometric) and penetration depth with respect to optical imaging and reduces scattering phenomena. In comparison with US a wider range of molecules can be used as PAI contrast agents. PAI allows to get 3D-high resolution images of soft tissues which provide anatomical, functional, and molecular information. The service includes animal model preparation, probes and image data processing and analysis.	EURO-BIOIMAGING	CAPI	hour	https://www.eurobioimaging.eu/nodes/center-for-advanced-preclinical-imaging-capi
*NEW 2.17b + 2.15i + 2.46i_SPECT/CT_a	FI	Intravital microscopy	A range of microscopy modalities used for imaging of living animal models, for the real-time visualization of cellular processes in their native environment in the living organism. It can be performed as repetitive imaging on the same animal, allowing biological processes to be tracked over long periods of time, or as acute experiments. Intravital microscopy can be used e.g. for the monitoring of the migration and cell-cell or cell-matrix interactions of invasive/metastatic tumor cells in different tissues.	EURO-BIOIMAGING	FiBI	complete access	https://www.eurobioimaging.eu/nodes/finnish-biomedical-imaging-node
*NEW 2.17c_SCANOMED_a	HU	Preclinical PET-MRI imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Medical&Preclinical HU	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
*NEW 2.15k + 2.46k + 2.17d_Semmelweis_a	HU	Preclinical PET-MRI imaging	Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) Imaging of animal models, for monitoring function and metabolism. PET and SPECT imaging can be performed as single modality acquisition but can also be used in combination with CT, for precise spatial localization of the PET/SPECT signals within the subject. The service includes radiotracer provision, animal model preparation, image data processing and analysis. Suitable radioisotopes and tracers can be selected based on the processes/targets that need to be visualized.	EURO-BIOIMAGING	Medical&Preclinical HU	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
*NEW 2.15k + 2.46k + 2.17d_Semmelweis_b	HU	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. Several quantitative MR imaging biomarkers can be used to monitor disease progression over time. The service includes animal model preparation, provision of contrast agents, image data processing and analysis.	EURO-BIOIMAGING	Medical&Preclinical HU	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
*NEW 2.15k + 2.46k + 2.17d_Semmelweis_c	HU	Preclinical UltraSound Imaging	UltraSound Imaging of animal models for visualizing and quantifying tumors, allowing staging, monitoring of therapeutic treatments, or guided injection of drugs. The use of targeting microbubbles as US contrast agents allows the visualization and quantification of specific tumor biomarkers as well. The service includes animal model preparation, probes, image data processing and analysis.	EURO-BIOIMAGING	Medical&Preclinical HU	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
*NEW 2.15k + 2.46k + 2.17d_Semmelweis_d	HU	Preclinical X-Rays Computed Tomography	X-rays Computed Tomography (CT) on tissues, organs or living animal models. CT contrast agents (usually based on Iodine, Barium, Gold) can be used to enhance the contrast. Preclinical microCT systems can be stand alone or integrated with other modalities like optical or nuclear medicine imaging in order to perform multimodal imaging. The service includes animal model prepartion, contrast agents if needed, image data processing and analysis.	EURO-BIOIMAGING	Medical&Preclinical HU	complete access	https://www.eurobioimaging.eu/nodes/medical-and-preclinical-imaging-hungary
*NEW 2.15q + 2.46q_micro PET_a	IT	Preclinical Magnetic Resonance Imaging	Magnetic resonance imaging (MRI) of animal models, comprising a large number of techniques for various applications ranging from simple morphological measurements to the evaluation of molecular processes at the cellular level. Used to monitor disease development and to test the efficacy of therapeutic treatments, to develop novel diagnostic tools etc. Several quantitative MR imaging biomarkers can be used to monitor disease progression over time. The service includes animal model preparation, provision of contrast agents, image data processing and analysis.	EURO-BIOIMAGING	Neuromed	complete access	https://www.eurobioimaging.eu/nodes/digital-imaging-multimodal-platform-neuromed---dimp-neuromed
*NEW 2.15ad + 2.46ad_MRI_a	PT	Human Magnetic Resonance Imaging	Human Magnetic resonance imaging (MRI). The service comprises support for subjects' enrolment and management of ethical requirements. At BIN, MRI can be used either as a single modality or paired to PET.	EURO-BIOIMAGING	Brain Imaging Network	hour	https://www.eurobioimaging.eu/nodes/brain-imaging-network-bin
*NEW2.12k + 2.33k + 2.40k_Semmelweis_1	HU	Atomic Force Microscopy	Atomic Force Microscopy (AFM) is a technique allowing the characterization of sample morphology at nanoscale. Images are acquired by raster scanning a nanometric tip in gentle contact or intermittent contact with the sample. The tip is positioned at the end of a micrometric force transducer, the AFM cantilever: it records the variation of sample topography due to changes of tip-sample interaction during scanning operation. In addition, by measuring the tip-sample interaction force as a function of the tip-sample distance, AFMs can evaluate sample elastic and viscous properties.	EURO-BIOIMAGING	Debrecen University	complet access	https://www.eurobioimaging.eu/nodes/cellular-imaging-hungary
*NEW2.12s + 2.33s + 2.40s_NorMIC_2	NO	Electron Microscopy	In transmission electron microscopy (TEM) the accelerated beam of electrons is transmitted through the sample and collected to form an image. To achieve this the specimen is usually sectioned into ultrathin sections less than 100 nm thick. Different methods for sample preparation are available	EURO-BIOIMAGING	University of Oslo	hour	https://www.eurobioimaging.eu/nodes/normic-oslo---advanced-light-microscopy-node-oslo
*NEW 2.12u + 2.33u + 2.40u_Instituto_2	PT	Electron Microscopy	Transmission electron microscopy for high-resolution sample imaging, including immuno-labelling and in-resin labelling	EURO-BIOIMAGING	Instituto de Biologica Molecular e Celular - IBCM	hour	https://www.eurobioimaging.eu/nodes/portuguese-platform-of-bioimaging-ppbi
*NEW 2.5 + 2.22 + 2.47_Instruct_EMBL_HD	DE	Electron Microscopy and Cryo-CLEM, Heidelberg, EMBL - canSERV	The Imaging Centre at EMBL Heidelberg gives access to state-of-the-art cryo-EM equipment for structure determination projects using the latest technology and methods in single-particle analysis, cryo-electron tomography (cryo-ET) and Cryo-correlative light and electron microscopy (Cryo-CLEM).	INSTRUCT-ERIC	Instruct Centre EMBL - EMBL Heidelberg	1 day	www.embl-hamburg.de/services/index.html
*NEW 2.5 + 2.22 + 2.47_Instruct_UH	FI	Electron Microscopy, Helsinki, Finland - canSERV	High-resolution cryoEM imaging of protein complexes to study their structure, assembly and function. Access is especially suitable for those wanting to screen samples and get small prelimianary datasets that can be used as proof of principle for access to 300 kV machines or for longer data collection. Correlative light microscopy and cryoEM is possible. Work with genetically modified organisms and BSL2 samples possible (please contact facility in advance). We accept both visits and shipped samples. Biomolecular complexes studied by cryoEM can be purified in the Biocomplex purification facility located in the same building.	INSTRUCT-ERIC	Instruct Centre FI - University of Helsinki	1 day	www.helsinki.fi/en
*NEW 2.5 + 2.22 + 2.47_Instruct_FR1	FR	Electron Microscopy, Strasbourg, France - canSERV	The center offers access for three-dimensional structure determination using cryo-electron microscopy (cryo-EM). The centre has expertise in all aspects of single particle analysis from the automated acquisition of large data sets to image analysis.	INSTRUCT-ERIC	Instruct Centre FR1 - IGBMC	1 day	www.igbmc.fr
*NEW 2.5 + 2.22 + 2.47_Instruct_FR2	FR	Electron Microscopy, Grenoble, France - canSERV	Services include quality control negative staining experiments prior to setting up cryo conditions; Data acquisition (single particle imaging and single axis tomography); Cellular EM services, such as plastic embbeding, tokuyasu method, high pressure freezing, immuno-labelling, ultra thin sectionning at room temperature and cryo. The slices can then be observed using a T12 or F20 electron microscope.	INSTRUCT-ERIC	Instruct Centre FR2 - IBS-ISBG	1 day	www.ibs.fr/?lang=en
*NEW2.5 + 2.22 + 2.47_Instruct_NECEN	NL	Electron Microscopy, NeCEN, Leiden, The Netherlands - canSERV	NeCEN is an open access facility for high resolution cryo-electron microscopy of biological samples. Two state-of-the-art Titan Krios transmission electron microscopes allow efficient and automated high resolution data collection in its two most broadly used forms, single particle analysis (SPA) and cryo-electron tomography (cryo-ET). These imaging techniques allow visualisation of biomolecular structures, such as proteins, macromolecular complexes, bacteria, and cell organelles at subnanometer resolution in close-to-native conditions. The facility is equipped with a BSL2 lab and microscope rooms.	INSTRUCT-ERIC	Instruct Centre NL - NeCEN LU	1 day	www.necen.nl
*NEW 2.5 + 2.22 + 2.47_Instruct_Diamond	UK	Electron Microscopy, Diamond Light Source, Harwell, UK - canSERV	The Electron Bio-Imaging Centre (eBIC) provides scientists with state-of-the-art experimental equipment and expertise in the field of cryo-electron microscopy, for both single particle analysis and cryo-tomography. Currently eBIC houses five Titan Krios microscopes, a Talos Arctica, Glacios, and a Scios and Aquilos cryo-FIB/SEM.	INSTRUCT-ERIC	Instruct Centre UK - Diamond Light Source	1 day	www.diamond.ac.uk
*NEW2.5 + 2.22 + 2.47_Instruct_ABSL	UK	Electron Microscopy, Leeds, UK - canSERV	Transmission electron microscopy of biological specimens, from small macromolecular complexes to cells, tissues and organisms. We have two state-of-the-art Titan Krios microscopes equipped with direct electron detectors (DED) for high resolution imaging. Both instruments have AFIS and Fringe free imaging.	INSTRUCT-ERIC	Instruct Centre UK - Astbury Biostructure Laboratory	1 day	www.astbury.leeds.ac.uk
*NEW2.5+2.22 + 2.47_Instruct_OPIC	UK	Electron Microscopy, Oxford, UK - canSERV	Access to state-of-the-art equipment for cryo-EM high-resolution single particle analysis, in-situ FIB-SEM and cryo-ET of biological specimens, from small macromolecular complexes to cells. Our facility includes equipment for grid preparation and optimisation (plunging devices and grid micro-patterning) and data collection (Titan Krios G3i, Aquilos 2). Equipment is located within biosafety containment laboratories (ACDP category 3 and DEFRA 4).	INSTRUCT-ERIC	Instruct Centre UK - Oxford Particle Imaging Centre	1 day	www.opic.ox.ac.uk
*NEW 2.9 + 2.36_Instruct_Diamond	UK	XChem Fragment Screening, Diamond Light Source, Harwell, UK - canSERV	Fragment screening through Macromolecular Crystallography at Diamond’s XChem facility at beamline I04-1, supporting 1000+ compound screens	INSTRUCT-ERIC	Instruct Centre UK - Diamond Light Source	1 day	www.diamond.ac.uk
*NEW2.8 + 2.20 + 2.23 + 2.35_Instruct_ULiege	BE	Robotein Automated Biomolecular Analysis, Liege, Belgium - canSERV	Numerous high-throughput (HT) assays are offered, such as HT biophysical characterisation (conformational stability (△G0) of proteins in the presence of chaotropic agents (e.g. urea, guanidinium chloride)); HT binding affinity measurements (enables real-time and label-free determination of binding affinity); HT protein quantitation form crude extracts (fast and accurate protein quantitation from crude extracts (cell extracts, culture media, etc.), with no required purification steps; particularly suitable to measure the concentration of full-length antibodies or various antibody fragments); HT enzymatic assays; HT screen of pH/buffer components (Protein formulation); HT screen of protein refolding conditions from inclusion bodies; Plasmaprofiling for metabolomics	INSTRUCT-ERIC	Instruct Centre BE - Robotein for Instruct	1 day	http://www.robotein.ulg.ac.be/
*NEW 2. 2.8 + 2.20 + 2.23 + 2.35_3.2_Instruct_CEITEC	CZ	Proteomic Mass Spectrometry and Molecular Biophysics, Brno, Czech Republic - canSERV	Complete mass spectrometry-assisted proteomics services from sample preparation/purification to qualitative/quantitative characterisation of proteins and their modifications by mass spectrometry and data processing. Services also comprise biophysical characterization of (bio)molecules and the study of biomolecular interactions (determination of affinity, kinetic and thermodynamic parameters). Techniques include analytical ultracentrifugation (AUC), isothermal titration calorimetry (ITC), surface plasmon resonance (SPR), bio-layer interferometry (BLI), microscale thermophoresis (MST), dynamic light scattering (DLS), differential scanning calorimetry (DSC), differential scanning fluorimetry (DSF), and analytical size-exclusion chromatography (SEC-MALS).	INSTRUCT-ERIC	Instruct Centre CZ - CEITEC	1 day	www.ceitec.eu
*NEW2. 2.8 + 2.20 + 2.23 + 2.35_3.2_Instruct_UEF	FI	Native Mass Spectrometry, Joensuu, Finland - canSERV	UEF core facility offers two state-of-the-art mass spectrometers for versatile utilization of native mass spectrometry for studies of protein folding and assembly of biological macromolecules as well as for quantitative biological interaction studies with large dynamic range.	INSTRUCT-ERIC	Instruct Centre FI - University of Eastern Finland	1 day	https://instruct-eric.org/centre/university-of-eastern-finland
*NEW. 2.8 + 2.20 + 2.23 + 2.35_3.2_Instruct_UH	FI	Single-cell Proteomics (SCoPE-MS), Helsinki, Finland - canSERV	SCoPE-MS offers a revolutionary technique enabling global level identification and quantification of single cell proteome (>1000 proteins) using mass spectrometry, exceeding the by >ten-fold the identification capability of fluorescence or mass cytometry. Single cell technologies on DNA and RNA level have recently become extremely popular, the SCoPE-MS will extend this to protein/proteome level.	INSTRUCT-ERIC	Instruct Centre FI - University of Helsinki	1 day	www.helsinki.fi/en
2. 2.8 + 2.20 + 2.23 + 2.35_3.2_Instruct_UU	NL	Mass Spectrometry, Utrecht, Netherlands - canSERV	Mass spectrometry based proteomics enables the identification and quantification of cellular proteins and their modified forms. The Biomolecular Mass Spectrometry and Proteomics group at the Bijvoet Centre provides access to qualitative proteomics analysis of proteins in complex samples. Instrumentation available includes advanced (2D)-HPLC and state-of-the-art mass spectrometers such as Thermo Scientific Q-Exactive Orbitraps.	INSTRUCT-ERIC	Instruct Centre NL - Bijvoet Centre	1 day	https://www.uu.nl/en/research/bijvoet-centre-for-biomolecular-research
2.8 + 2.20 + 2.23 + 2.35_Instruct_ICSAS	SK	Mass Spectrometry - Glycan Analysis, Bratislava, Slovakia - canSERV	Glycan structure analysis by applying spectroscopic methods, such as Protein Mass spectrometry using an Orbitrap Elite mass spectrometer, coupled with HPLC/nanoLC or Native Mass Spectrometry using an UltrafleXtreme II MALDI mass spectrometer, coupled with nanoLC	INSTRUCT-ERIC	Instruct Research Site SK - ICSAS	1 day	www.sav.sk/?lang=en
2. 2.8 + 2.20 + 2.23 + 2.35_3.2_Instruct_ABSL	UK	Mass Spectrometry, Leeds, UK - canSERV	Services include hydrogen/deuterium exchange (HDX)-MS analyses to determine protein folding states, effects of ligand binding and protein interactions (e.g. epitope mapping); Covalent labelling setup for hydroxyl radical foot printing via Fast Photochemical Oxidation of Proteins (FPOP) linked to mass spectrometry, to probe changes in solvent accessibility; High-resolution native MS (for heterogeneous systems at high mass-to-charge ratios, e.g. membrane protein lipid complexes); Ion mobility capabilities	INSTRUCT-ERIC	Instruct Centre UK - Astbury Biostructure Laboratory	1 day	www.astbury.leeds.ac.uk
1. 2.7 + 2.19 + 2.23 + 2.37_3.1_Instruct_GUF	DE	Solution NMR, Frankfurt, Germany - canSERV	This service provides access to NMR spectrometers in the range of proton frequencies from 600 MHz to 950 MHz to elucidate the structure and funtional mechanism of biomolecules, such as proteins, RNA, ligand-protein and ligand-RNA complexes.	INSTRUCT-ERIC	Goethe University Frankfurt	1 day
1. 2.7 + 2.19 + 2.23 + 2.37_3.1_Instruct_UH	FI	NMR, Helsinki, Finland - canSERV	The NMR facility provides services on the field of liquid NMR. The main focus area includes studies of structure and dynamics of biomacromolecules, but also other types of analyses are very well possible e.g. with broadband probe on 600 MHz.	INSTRUCT-ERIC	Instruct Centre FI - University of Helsinki	1 day	www.helsinki.fi/en
1. 2.7 + 2.19 + 2.23 + 2.37_3.1_Instruct_FR2	FR	NMR, Grenoble, France - canSERV	Access to solid state NMR equipment with state-of-the-art magic-angle spinning (MAS) capabilities, and triple-resonance probes for different rotor sizes and spinning speeds. High-sensitivity solution-state NMR applications are also offered using instruments with Bruker electronics (Avance III HD) and cryogenically cooled probes. Standard Bruker experiment libraries and additional in-house libraries for optimised fast NMR data acquisition (e.g. SOFAST, BEST, HADAMAC-type experiments) are available. Fast-mixing equipments required for real-time studies of kinetic processes, e.g. protein folding are also available.	INSTRUCT-ERIC	Instruct Centre FR2 - IBS-ISBG	1 day	www.ibs.fr/?lang=en
1. 2.7 + 2.19 + 2.23 + 2.37_3.1_Instruct_CERM	IT	NMR, Florence, Italy - canSERV	Solid-state and solution NMR for structure and dynamic characterisation of biological macromolecules and their complexes; “protonless” NMR experiments and in-cell NMR spectroscopy, tailored pulse sequences for structural determination of paramagnetic systems; Relaxometry (structural and dynamical information on nuclear spin systems); Electron Paramagnetic Resonance (EPR)-based methods to map local dynamic and structural features of biomolecules, to explore different modes of biomolecule-ligand interaction, to obtain long-range structural restraints and to probe metal-ion-binding sites.	INSTRUCT-ERIC	Instruct Centre IT - CERM/CIRMMP	1 day	www.cerm.unifi.it
1. 2.7 + 2.19 + 2.23 + 2.37_3.1_Instruct_UU	NL	NMR, Utrecht, Netherlands - canSERV	Solid state and solution NMR equipment for the characterisation of biomolecules, their structure determination and dynamical and functional studies. Services also include structural determination of high molecular weight proteins or complexes, such as nucleosome-protein complexes (200-250 kDa) and other special applications, such as in-cell NMR experiments. Support for applications involving interactions of intrinsically disordered proteins as well as support for medium to high-througput screening.	INSTRUCT-ERIC	Instruct Centre NL - Bijvoet Centre - UU	1 day	https://www.uu.nl/en/research/bijvoet-centre-for-biomolecular-research
1. 2.7 + 2.19 + 2.23 + 2.37_3.1_Instruct_ABSL	UK	Solution NMR, Leeds, UK - canSERV	This service offeres solution NMR based on direct heteronuclear detection (15N and 13C, 5mm TXO Cryoprobe). Combination of high field and Carbon detection for complex or large intrinsically disordered proteins and characterisation of protein sidechains. Techniques using 15N detection are under development and are of interest in chemically exchanging systems, as an alternative to Ca detection and when deuteration is not feasible. Solution NMR services for mass limited samples and high ionic strength samples using a smaller diameter probe (3mm TCI Cryoprobe) for optimised sensitivity.	INSTRUCT-ERIC	Instruct Centre UK - Astbury Biostructure Laboratory	1 day	www.astbury.leeds.ac.uk
2.4 + 2.39_Instruct_UH	FI	Biomolecular Complex Purification (Biocomplex), Helsinki, Finland - canSERV	Sample preparation and purification for functional and structural studies using preparative ultracentrifugation, monolithic chromatography and asymmetrical flow field-flow fractionation technologies. These can be used in different combinations to purify large macromolecular complexes such as viruses, exosomes, membrane vesicles, large protein complexes, and ribonucleoprotein complexes. Samples produced at Biocomplex can be further studied at the CryoEM facility located in the same building. We accept both visits and shipped samples.	INSTRUCT-ERIC	Instruct Centre FI - University of Helsinki	1 day	www.helsinki.fi/en
2.4 + 2.39_Instruct_FR1	FR	Protein Production and Gene Tagging, Strasbourg, France - canSERV	Recombinant expression of protein and multi-protein complexes in prokaryotic and eukaryotic hosts as well as biomass production for isolation of poorly abundant proteins and endogenous complexes; Gene tagging with the CRISPR-Cas9 system for introduction of affinity tags to facilitate the purification of endogenous complexes or for tagging proteins with fluorescent reporters in view of imaging and functional proteomics applications, in the frame of a partnership with the TacGene platform from the Museum d’Histoire Naturelle (Paris, France).	INSTRUCT-ERIC	Instruct Centre FR1 - IGBMC	1 day	www.igbmc.fr
2.4 + 2.39_Instruct_WIS	IL	Protein Production, Weizmann Istitute, Israel - canSERV	Protein production in bacteria, baculovirus, and mammalian cells. Proteins are typically purified following a standard 3 step protocol which includes: affinity capture, ion exchange and size exclusion. Specific techniques can be employed depending on the protein, the experimental requirements, tags and yields. Removal of tags with TEV protease can be employed.	INSTRUCT-ERIC	Instruct Centre IL - Weizmann Institute of Science	1 day	http://www.weizmann.ac.il/ISPC/
2.4 + 2.39_Instruct_NKI	NL	Protein Production in Insect and Mammalian Cells, Amsterdam, Netherlands - canSERV	Protein production using insect and mammalian cells, and assisting users with the design of their expression construct in terms of solubility, domain boundaries, etc. We offer a variety of expression vectors, including a set of LIC vectors (Ligand Independent Cloning). For expression of intracellular and extracellular proteins in insect cells we have SF9 and SF21 systems. Our mammalian expression system has been optimized for HEK-293T cells, and we also have the glycosylation free, gnT1-deficient HEK293S variety. Protein expression in bacteria (E. coli) is beyond the scope of the facility.	INSTRUCT-ERIC	Instruct Centre NL - Netherlands Cancer Institute	1 day	https://www.nki.nl/research/facilities-platforms/protein-facility/
2.4 + 2.39_Instruct_EMBL_HH	DE	Molecular Biophysics, Hamburg, Germany - canSERV	Services for protein quality control in addition to biophysical characterization techniques for studying the interaction of biomolecules, including MALDI (MS), Thermofluor (TF), Circular Dichroism (CD), Fourier-transform infrared spectroscopy (FTIR), Isothermal Titration Calorimetry (ITC), nano Differential Scanning Fluorimetry (nDSF), Surface Plasmon Resonance (SPR), Biolayer interferometry (Octet), Microscale Thermophoresis (MST), Dynamic Light Scattering (DLS), Mass Photometry (Refeyn), Ligand screening kinetics (Creoptix-WAVE) and time resolved reactions (stopped-flow).	INSTRUCT-ERIC	Instruct Centre EMBL - EMBL Hamburg	1 day	www.embl-hamburg.de/services/index.html
2.10 + 2.19_Instruct_BIOCEV	CZ	X-ray Diffraction and Bio-SAXS, Vestec near Prague, Czech Republic - canSERV	Crystallization of biomacromolecules and their complexes as well as services for characterization of protein structures using single crystal X-ray diffraction and small-angle X ray scattering for analysis of liquid samples. The quality of high-intense X-ray beams is ensured by using of MetalJet sources (Excillum). The provided services include assistance with data processing and reporting ready for publication.	INSTRUCT-ERIC	Instruct Centre CZ - BIOCEV	1 day	www.biocev.eu
2.10 + 2.19_Instruct_EMBL_HH	DE	X-ray Diffraction and Bio-SAXS, Hamburg, Germany - canSERV	Macromolecular crystallography and biological small-angle X-ray scattering (SAXS). SAXS allows one to study the overall (quaternary) structure and structural transitions in a non-restrictive sample environment, directly in solution. Examples of services offered are: (i) combinatorial high throughput ligands/additives screening; (ii) studies of equilibrium mixtures and membrane proteins with online SEC-SAXS coupled with biophysical analysis, and (iii) time-resolved studies of processes, from sub-ms ((un)folding) to hours (oligomerization, fibrillation). Sample preparation and characterisation (crystallization screens suitable for soluble and membrane proteins), processing and evaluation of the data.	INSTRUCT-ERIC	Instruct Centre EMBL - EMBL Hamburg	1 day	www.embl-hamburg.de/services/index.html
2.18l_IRST IRCCS_b	IT	RNA sequencing	total RNA or mRNA sequencing in tumoral and/ or non tumoral samples using NGS technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	IRST IRCSS	sample	www.irst.emr.it
2.18j_CNAG_b	ES	RNA sequencing	total RNA or mRNA sequencing in tumoral and/ or non tumoral samples using NGS technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG	1Gb sequence data	https://www.cnag.crg.eu/
2.18f_UL Biobank_a	PL	Whole Genome Sequencing	Whole genome sequencing in tumoral and non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	Biobank Lab of the University of Lodz	sample	www.biobank.uni.lodz.pl
2.18f_UL Biobank_b	PL	RNA sequencing	RNA sequencing in tumoral/ non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	Biobank Lab of the University of Lodz	sample	www.biobank.uni.lodz.pl
2.18f_UL Biobank_c	PL	Whole Exome Sequencing	Whole exome sequencing in tumoral and non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	Biobank Lab of the University of Lodz	sample	www.biobank.uni.lodz.pl
2.18f_UL Biobank_d	PL	16S rRNA microbiome sequencing	Microbial profiling by sequencing 16S ribosomal RNA (rRNA) with next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	Biobank Lab of the University of Lodz	sample	www.biobank.uni.lodz.pl
2.18f_UL Biobank_e	PL	Metagenomic microbiome sequencing	Microbial profiling by shotgun metagenomics using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	Biobank Lab of the University of Lodz	sample	www.biobank.uni.lodz.pl
*NEW 2.18k_UNIMIB Med_a	IT	Exome sequencing	Whole exome sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	UNIMIB_MED	cell	https://en.unimib.it/
*NEW 2.18k_UNIMIB Med_b	IT	Target DNA sequencing: custom gene panels	Target sequencing of custom gene panels in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	UNIMIB_MED	cell	https://en.unimib.it/
*NEW2.18k_UNIMIB Med_c	IT	RNA sequencing	total RNA or mRNA sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	UNIMIB_MED	cell	https://en.unimib.it/
2.18l_IRST IRCCS_c	IT	Whole exome sequencing	Whole exome sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	IRST IRCSS	sample	www.irst.emr.it
2.18l_IRST IRCCS_d	IT	Target DNA sequencing: custom gene panels	Target sequencing of custom gene panels in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	IRST IRCSS	sample	www.irst.emr.it
2.18j_CNAG_c	ES	Whole exome sequencing	Whole exome sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG - CRG	1Gb sequence data	https://www.cnag.crg.eu/
2.18j_CNAG_d	ES	Whole genome enzymatic methyl sequencing	Whole genome enzymatic methyl sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG - CRG	1Gb sequence data	https://www.cnag.crg.eu/
2.18j_CNAG_e	ES	Single cell ATAC sequencing	Single cell ATAC (assay for transposase-accessible chromatin) sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG - CRG	1Gb sequence data	https://www.cnag.crg.eu/
2.18l_IRST IRCCS_e	IT	smallRNA sequencing	smallRNA sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	IRST IRCSS	sample	www.irst.emr.it
2.18l_IRST IRCCS_f	IT	Single cell mRNA sequencing	Single cell mRNA sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	IRST IRCSS	sample	www.irst.emr.it
2.18l_IRST IRCCS_g	IT	Spatial transcriptomics	Spatial transcriptomics in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	IRST IRCSS	sample	www.irst.emr.it
2.18j_CNAG_f	ES	Single cell mRNA sequencing	Single cell mRNA sequencing in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG - CRG	1Gb sequence data	https://www.cnag.crg.eu/
2.18j_CNAG_g	ES	Single cell immune repertoire profiling	Single cell immune repertoire profiling (TCR/ BCR) in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG - CRG	1Gb sequence data	https://www.cnag.crg.eu/
2.18j_CNAG_h	ES	Spatial transcriptomics	Spatial transcriptomics in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	CNAG - CRG	1Gb sequence data	https://www.cnag.crg.eu/
2.18u_Single cell _LIED_b	DE	Single cell immune repertoire profiling	Single cell immune repertoire profiling (TCR/ BCR) in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	LIED, University of Lubeck	sample
2.18u_Single cell _LIED_c	DE	Spatial transcriptomics	Spatial transcriptomics in tumoral and/ or non tumoral samples using next generation sequencing technologies	BIOBANKS AND BIOMOLECULAR RESOURCES RESEARCH INFRASTRUCTURE CONSORTIUM (BBMRI-ERIC)	LIED, University of Lubeck	sample

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