Call: Challenge Call for “Service Provision on Advancing Personalised Oncology”

Project: “Development of a novel clinically applicable lipase inhibitor for personalised treatment of triple negative breast cancer and pancreatic ductal adenocarcinoma”

canSERV support: canSERV enables Knud to transfer his established screening setup to a high-throughput facility (Centre of Molecular Medicine Norway, Oslo). A high-quality compound library, containing 100,000 substances, is provided by EU-OPENSCREEN (Berlin).

Call: Challenge Call for Service provision on” Advancing Personalised Oncology”

Project: “Biomarker(s) predicing bevacizumab treatment response and alternative therpeutic targets in metastatic colorectal cancer.”

canSERV support: canSERV gives Pavla free-of-charge access to a large set (>1,000) of suitable biobank samples and high-quality services (genomics, proteomics, and transcriptomics). These interconnected datasets will be analysed with AI-support.

Call: Open Call for Service Provision

Project: “Anti-metastatic RNA aptamers for the treatment of EphA2-positive cancers”

canSERV support: The five granted services include protein production & X-ray crystallography (to characterise the aptamer binding site on EphA2) and biophysical analyses (BLI, to determine binding specificity/affinity). RNA sequencing and phospho-proteomics address changes of the affected signalling cascade. Finally, the project addresses the regulatory path to clinical application.

Call: Open Call for Service Provision

Project: “Whole exome sequencing to advance melanoma early detection”

canSERV support: “Through canSERV, Dace’s team will perform whole exome sequencing (Uni Łódź) of DNA samples from Melanoma patients recruited for the Latvian Genome database (LGDB). With a second canSERV partner (IFO, Rome), Dace’s team will be trained to search the datasets for unknown causal genes for Melanoma and related cancer types.”

Call: Challenge Call for “Service Provision on Advancing Personalised Oncology”

Project: “Development of a novel clinically applicable lipase inhibitor for personalised treatment of triple negative breast cancer and pancreatic ductal adenocarcinoma”

canSERV support: canSERV enables Knud to transfer his established screening setup to a high-throughput facility (Centre of Molecular Medicine Norway, Oslo). A high-quality compound library, containing 100,000 substances, is provided by EU-OPENSCREEN (Berlin).

Call: Challenge Call for Service provision on” Advancing Personalised Oncology”

Project: “Biomarker(s) predicing bevacizumab treatment response and alternative therpeutic targets in metastatic colorectal cancer.”

canSERV support: canSERV gives Pavla free-of-charge access to a large set (>1,000) of suitable biobank samples and high-quality services (genomics, proteomics, and transcriptomics). These interconnected datasets will be analysed with AI-support.

Call: Open Call for Service Provision

Project: “Anti-metastatic RNA aptamers for the treatment of EphA2-positive cancers”

canSERV support: The five granted services include protein production & X-ray crystallography (to characterise the aptamer binding site on EphA2) and biophysical analyses (BLI, to determine binding specificity/affinity). RNA sequencing and phospho-proteomics address changes of the affected signalling cascade. Finally, the project addresses the regulatory path to clinical application.

Call: Open Call for Service Provision

Project: “Whole exome sequencing to advance melanoma early detection”

canSERV support: “Through canSERV, Dace’s team will perform whole exome sequencing (Uni Łódź) of DNA samples from Melanoma patients recruited for the Latvian Genome database (LGDB). With a second canSERV partner (IFO, Rome), Dace’s team will be trained to search the datasets for unknown causal genes for Melanoma and related cancer types.”

Call: Challenge Call for “Service Provision on Advancing Personalised Oncology”

Project: “Development of a novel clinically applicable lipase inhibitor for personalised treatment of triple negative breast cancer and pancreatic ductal adenocarcinoma”

canSERV support: canSERV enables Knud to transfer his established screening setup to a high-throughput facility (Centre of Molecular Medicine Norway, Oslo). A high-quality compound library, containing 100,000 substances, is provided by EU-OPENSCREEN (Berlin).

Call: Challenge Call for Service provision on” Advancing Personalised Oncology”

Project: “Biomarker(s) predicing bevacizumab treatment response and alternative therpeutic targets in metastatic colorectal cancer.”

canSERV support: canSERV gives Pavla free-of-charge access to a large set (>1,000) of suitable biobank samples and high-quality services (genomics, proteomics, and transcriptomics). These interconnected datasets will be analysed with AI-support.

Call: Open Call for Service Provision

Project: “Anti-metastatic RNA aptamers for the treatment of EphA2-positive cancers”

canSERV support: The five granted services include protein production & X-ray crystallography (to characterise the aptamer binding site on EphA2) and biophysical analyses (BLI, to determine binding specificity/affinity). RNA sequencing and phospho-proteomics address changes of the affected signalling cascade. Finally, the project addresses the regulatory path to clinical application.

Call: Open Call for Service Provision

Project: “Whole exome sequencing to advance melanoma early detection”

canSERV support: “Through canSERV, Dace’s team will perform whole exome sequencing (Uni Łódź) of DNA samples from Melanoma patients recruited for the Latvian Genome database (LGDB). With a second canSERV partner (IFO, Rome), Dace’s team will be trained to search the datasets for unknown causal genes for Melanoma and related cancer types.”

Call: Challenge Call for “Service Provision on Advancing Personalised Oncology”

Project: “Development of a novel clinically applicable lipase inhibitor for personalised treatment of triple negative breast cancer and pancreatic ductal adenocarcinoma”

canSERV support: canSERV enables Knud to transfer his established screening setup to a high-throughput facility (Centre of Molecular Medicine Norway, Oslo). A high-quality compound library, containing 100,000 substances, is provided by EU-OPENSCREEN (Berlin).

Call: Challenge Call for Service provision on” Advancing Personalised Oncology”

Project: “Biomarker(s) predicing bevacizumab treatment response and alternative therpeutic targets in metastatic colorectal cancer.”

canSERV support: canSERV gives Pavla free-of-charge access to a large set (>1,000) of suitable biobank samples and high-quality services (genomics, proteomics, and transcriptomics). These interconnected datasets will be analysed with AI-support.

Call: Open Call for Service Provision

Project: “Anti-metastatic RNA aptamers for the treatment of EphA2-positive cancers”

canSERV support: The five granted services include protein production & X-ray crystallography (to characterise the aptamer binding site on EphA2) and biophysical analyses (BLI, to determine binding specificity/affinity). RNA sequencing and phospho-proteomics address changes of the affected signalling cascade. Finally, the project addresses the regulatory path to clinical application.

Call: Open Call for Service Provision

Project: “Whole exome sequencing to advance melanoma early detection”

canSERV support: “Through canSERV, Dace’s team will perform whole exome sequencing (Uni Łódź) of DNA samples from Melanoma patients recruited for the Latvian Genome database (LGDB). With a second canSERV partner (IFO, Rome), Dace’s team will be trained to search the datasets for unknown causal genes for Melanoma and related cancer types.”